Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Powles, Thomas; S van der Heijden, Michiel; Castellano, Daniel; D Galsky, Matthew; Loriot, Yohann; P Petrylak, Daniel; Ogawa, Osamu; Hoon Park, Se; Lee, Jae-Lyun; De Giorgi, Ugo; Bögemann, Martin; Bamias, Aristotelis; J Eigl, Bernhard; Gurney, Howard; D Mukherjee, Som; Fradet, Yves; Skoneczna, Iwona; Tsiatas, Marinos; Novikov, Andrey; Suárez, Cristina; P Fay, André; Duran, Ignacio; Necchi, Andrea; Wildsmith, Sophie; He, Philip; Angra, Natasha; K Gupta, Ashok; Levin, Wendy; Bellmunt, Joaquim; Hoon Park, Se; S. van der Heijden, Michiel; Necchi, Andrea; Castellano, Daniel; Bamias, Aristotelis; Lyun Lee, Jae; De Giorgi, Ugo; Bögemann, Martin; J. Eigl, Bernhard; Tsiatas, Marinos; Powles, Thomas; Novikov, Andrey; Skoneczna, Iwona; D. Mukherjee, Som; Suarez, Cristina; Westgeest, Hans; Fradet, Yves; Flechon, Aude; Ou, Yen-Chuan; Park, Inkeun; Matveev, Vsevolod; Pérez-Valderrama, Begoña; Cheng, Susanna; Frank, Stephen; Gurney, Howard; Anido, Urbano; Hamzaj, Alketa; Retz, Margitta; Sridhar, Srikala; Vittorio Scagliotti, Giorgio; Voortman, Jens; Alekseev, Boris; Alyasova, Anna; Komyakov, Boris; Dumez, Herlinde; Pavic, Michel; Kimura, Go; Mizokami, Atsushi; Osanto, Susanne; Angel Arranz, Jose; Piersma, Djura; Joon Shin, Sang; Karyakin, Oleg; Delgado, Ignacio; Luis Gonzalez, Jose; Pang, See-Tong; Tran, Anna; Lipatov, Oleg; Su, Wen-Pin; Flaig, Thomas; Alva, Ajjai; Park Kyong, Hwa; Kopyltsov, Evgeny; Almagro, Elena; Domenech, Monserrat; Chang, Yen-Hwa; Sautois, Brieuc; Ravaux, Andre; Aravantinos, Gerasimos; Georgoulias, Vasileios; Mulder, Sasja; Jung Kim, Yu; Kater, Fabio; Chevreau, Christine; Tagawa, Scott; Zalewski, Pawel; Joly, Florence; Loriot, Yohann; Hatiboglu, Gencay; Gianni, Luca; Morelli, Franco; Tambaro, Rosa; Hashimoto, Yasuhiro; Nosov, Alexander; Font, Albert; M. Rodriguez-Vida, Alejo; Jones, Robert; Vasudev, Naveen; Srinivas, Sandhya; Zhang, Jingsong; Gil, Thierry; Finch, Daygen; Grimm, Marc-Oliver; Su, Yu-Li; Chowdhury, Simon; Hocking, Christopher; Plas, Eugen; North, Scott; Viggo Jensen, Niels; Theodore, Christine; Imkamp, Florian; Peer, Avivit; Kobayashi, Takashi; Sakai, Hideki; Sassa, Naoto; Yoshimura, Kazuhiro; Aarts, Maureen; Ferreira Castro, Ana; Topuzov, Marlen; Francisco Rodriguez, Juan; Jose Vazquez, Federico; Tsai, Yu-Chieh; Crabb, Simon; Hussain, Syed; Bendell, Johanna; Gross-Goupil, Marine; Gwenaelle, Gravis; Berger, Raanan; Statsenko, Galina; Evans, Linda; Drakaki, Alexandra; Somer, Bradley; Davis, Ian; Lynam, James; Borges, Giuliano; Dettino, Aldo; P. Fay, André; Martins, Graziella; Eduardo Zucca, Luis; Agerbaek, Mads; Kalofonos, Haralambos; Rosenbaum, Eli; Enokida, Hideki; Kikukawa, Hiroaki; Nishimura, Kazuo; Tamada, Satoshi; Uemura, Motohide; Lopez, Yamil; Gietema, Jourik; Slojewski, Marcin; Fernandes, Isabel; Smolin, Alexey; Mazhar, Danish; Rezazadeh Kalebasty, Arash; Carthon, Bradley; Loidl, Wolfgang; Franke, Fabio; Girotto, Gustavo; Alimohamed, Nimira; Macfarlane, Robyn; Pappot, Helle; Niegisch, Guenter; Mavroudis, Dimitrios; Sella, Avishay; Porta, Camillo; Ebara, Shin; Nakamura, Motonobu; Obara, Wataru; Okuno, Norihiko; Shinohara, Nobuo; Sugimoto, Mikio; Suzuki, Akitaka; Tokuda, Noriaki; Uemura, Hiroji; Yamaguchi, Akito; Ramirez, Francisco; Rozanowski, Pawel; Wiechno, Pawel; Keam, Bhumsuk; Kislov, Nikolay; Plaksin, Denis; Cicin, Irfan; Kumar, Satish; D. Galsky, Matthew; P. Petrylak, Daniel; Rosales, Joseph; Vaishampayan, Ulka; Culine, Stephane; Papandreou, Christos; Nara, Taketoshi; Erman, Mustafa

doi:10.1016/s1470-2045(20)30541-6

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Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Shared by NobleBlocks on Dec 1, 2020 • 12:00 AM UTC

Authors:

Thomas Powles

Michiel S van der Heijden

Daniel Castellano

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