Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Zhang, Qian; Bastard, Paul; Liu, Zhiyong; Le Pen, Jérémie; Moncada‐Vélez, Marcela; Chen, Jie; Ogishi, Masato; K. D. Sabli, Ira; Hodeib, Stephanie; B. Korol, Cecilia; Rosain, Jérémie; Bilgüvar, Kaya; Ye, Junqiang; Bolze, Alexandre; Bigio, Benedetta; Yang, Rui; A. Arias, Andrés; Zhou, Qinhua; Zhang, Yu; Onodi, Fanny; Korniotis, Sarantis; Karpf, Léa; Philippot, Quentin; Chbihi, Marwa; Bonnet‐Madin, Lucie; Dorgham, Karim; Smith, Nikaïa; M. Schneider, William; S. Razooky, Brandon; Hoffmann, Hans-Heinrich; Michailidis, Eleftherios; Moens, Leen; Eun Han, Ji; Lorenzo, Lazaro; Bizien, Lucy; Meade, Philip; Neehus, Anna‐Lena; Ugurbil, Aileen; Corneau, Aurélien; Kerner, Gaspard; Zhang, Peng; Rapaport, Franck; Seeleuthner, Yoann; Manry, Jérémy; Masson, Cécile; Schmitt, Yohann; Schlüter, Agatha; Le Voyer, Tom; Khan, Taushif; Li, Juan; Fellay, Jacques; Roussel, Lucie; Shahrooei, Mohammad; F. Alosaimi, Mohammed; Mansouri, Davood; Al‐Saud, Haya; Al‐Mulla, Fahd; Almourfi, Feras; Zaid Al-Muhsen, Saleh; Alsohime, Fahad; Al Turki, Saeed; Hasanato, Rana; van de Beek, Diederik; Biondi, Andrea; Rachele Bettini, Laura; D’Angiò, Mariella; Bonfanti, Paolo; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quirós-Roldán, Eugenia; Rossi, Camillo; J. Oler, Andrew; F. Tompkins, Miranda; Alba, Camille; Vandernoot, Isabelle; Goffard, Jean‐Christophe; Smits, Guillaume; Migeotte, Isabelle; Haerynck, Filomeen; Soler‐Palacín, Pere; Martín-Nalda, Andrea; Colobrán, Roger; Morange, Pierre‐Emmanuel; Keleş, Sevgi; Çölkesen, Fatma; Özçelık, Tayfun; Kart Yaşar, Kadriye; Şenoğlu, Sevtap; Nur Karabela, Şemsi̇; Rodríguez‐Gallego, Carlos; Novelli, Giuseppe; Hraiech, Sami; Tandjaoui-Lambiotte, Yacine; Duval, Xavier; Laouenan, Cédric; COVID Group, Imagine; COVID Cohort Study Group, French; Cohort, CoV-Contact; UMC Covid-19 Biobank, Amsterdam; Human Genetic Effort, COVID; COVID Immunity Group, NIAID-USUHS/TAGC; L. Snow, Andrew; L. Dalgard, Clifton; D. Milner, Joshua; C. Vinh, Donald; H. Mogensen, Trine; Marr, Nico; N. Spaan, András; Boisson, Bertrand; Boisson‐Dupuis, Stéphanie; Bustamante, Jacinta; Puel, Anne; J. Ciancanelli, Michael; Meyts, Isabelle; Maniatis, Tom; Soumelis, Vassili; Amara, Ali; C. Nussenzweig, Michel; García‐Sastre, Adolfo; Krammer, Florian; Pujol, Aurora; Duffy, Darragh; P. Lifton, Richard; Zhang, Shen‐Ying; Gorochov, Guy; Béziat, Vivien; Jouanguy, Emmanuelle; Sancho‐Shimizu, Vanessa; M. Rice, Charles; Abel, Laurent; D. Notarangelo, Luigi; Cobat, Aurélie; C. Su, Helen; Casanova, Jean‐Laurent; Foti, Giuseppe; Bellani, Giacomo; Citerio, Giuseppe; Contro, Ernesto; Pesci, Alberto; Grazia Valsecchi, Maria; Elena Cazzaniga, Marina; Abad, Jorge; Aguilera, Sergio; Metin Akcan, Özge; Alavi Darazam, Ilad; C. Aldave, Juan; Alfonso Ramos, Miquel; Alireza Nadji, Seyed; Alkan, Gülsüm; Allardet-Servent, Jérôme; M. Allende, Luís; Alsina, Laia; Alyanakian, Marie‐Alexandra; Amador-Borrero, Blanca; Amoura, Zahir; Antolí, Arnau; Arslan, Şevket; Trouillet‐Assant, Sophie; Auguet, Terese; Azot, Axelle; Bajolle, Fanny; Baldolli, Aurélie; Ballester, Mayte; Baris Feldman, Hagit; Barrou, Benoı̂t; Beurton, Alexandra; Bilbao, Agurtzane; Blanchard‐Rohner, Géraldine; Blanco, Ignacio; Blandinières, Adeline; Blázquez‐Gamero, Daniel; Bloomfield, Markéta; Bolívar-Prados, Mireia; Borie, Raphaël; Bosteels, Cédric; A. Bousfiha, Ahmed; Bouvattier, Claire; Boyarchuk, Oksana; Rita Passos‐Bueno, Maria; Bustamante, Jacinta; José Cáceres Agra, Juan; Calimli, Semra; Capra, Ruggero; Carrabba, Maria; Casasnovas, Carlos; Caséris, Marion; Castelle, Martin; Castelli, Francesco; Castillo de Vera, Martín; Vidigal de Castro, Mateus; Catherinot, Émilie; Chalumeau, Martin; Charbit, Bruno; P. Cheng, Matthew; Clavé, Père; Clotet, Bonaventura; Codina, Anna; Çölkesen, Fatih; Çölkesen, Fatma; Colobrán, Roger; Comarmond, Cloé; Dalmau, David; Darley, D.R.; Dauby, Nicolás; Dauger, Stéphane; de Pontual, Loïc; Dehban, Amin; Delplancq, Geoffroy; Demoule, Alexandre; Diehl, Jean‐Luc; Dobbelaere, Stephanie; Durand, Sophie; Eldars, Waleed; Elgamal, Mohamed; H. Elnagdy, Marwa; Emiroğlu, Melike; Hafize Erdeniz, Emine; Erol Aytekin, Selma; Euvrard, Romain; Evcen, Recep; Fabio, Giovanna; Faivre, Laurence; Falck, Antonin; Fartoukh, Muriel; Faure, Morgane; Fernández‐Arquero, Miguel; Flores, Carlos; François, Bruno; Fumadó, Victòria; Fusco, Francesca; García‐Solis, Blanca; Gaussem, Pascale; Gil-Herrera, Juana; Gilardin, Laurent; Girona Alarcón, Mònica; Girona‐Alarcón, Mònica; Goffard, Jean-Christophe; Gök, Funda; González‐Montelongo, Rafaela; Guerder, Antoine; Gül, Yahya; Nail Güner, Şükrü; Gut, Marta; Hadjadj, Jérôme; Haerynck, Filomeen; Halwani, Rabih; Hammarström, Lennart; Hatipoğlu, Nevin; Hernández-Brito, Elisa; Heijmans, Cathérine; Soledad Holanda-Peña, María; Pablo Horcajada, Juan; Hoste, Levi; A. J. Hoste, Eric; Hraiech, Sami; Humbert, L.; Iglesias, Alejandro; Íñigo-Campos, Antonio; Jamme, Matthieu; J. Arranz, María; Jordán, Iolanda; G. Jorens, Philippe; Kanat, Fikret; Kapaklı, Hasan; Kara, İskender; Karbuz, Adem; Kart Yasar, Kadriye; Keles, Sevgi; Kendir Demirkol, Yasemin; Klocperk, Adam; Król, Zbigniew; Kuentz, Paul; Wah M. Kwan, Yat; Lagier, Jean‐Christophe; N. Lambrecht, Bart; Lau, YL; Le Bourgeois, Fleur; Leo, Yee‐Sin; León‐López, Rafael; Leung, Daniel; Levin, Michael; Levy, Michaël; Lévy, Romain; Li, Zhi; Linglart, Agnès; Loeys, Bart; M. Lorenzo-Salazar, José; Louapre, Céline; Lubetzki, Catherine; Luyt, Charles‐Édouard; Chien Lye, David; Mansouri, Davood; Marjani, Majid; Marquez Pereira, Jesus; Martín‐Nalda, Andrea; Martínez Pueyo, David; Martínez‐Picado, Javier; Marzana, Iciar; Mathian, Alexis; R. B. Matos, Larissa; Matthews, Gail; Mayaux, Julien; Mège, Jean‐Louis; Melki, Isabelle; Méritet, Jean–François; Metin Akcan, Özge; Meyts, Isabelle; Mezidi, Mehdi; Migeotte, Isabelle; Millereux, Maude; Mirault, Tristan; Mircher, Clotilde; Mirsaeidi, Mehdi; Montesdeoca Melián, Abián; Morales Martínez, Antonio; Morange, Pierre‐Emmanuel; Mordacq, C.; Morelle, Guillaume; Mouly, Stéphane; Muñoz‐Barrera, Adrián; Naesens, Leslie; Nafati, Cyril; Farela Neves, João; F. P. Ng, Lisa; Nóvoa Medina, Yeray; Núñez Cuadros, Esmeralda; Gonzalo Ocejo‐Vinyals, J.; Orbak, Zerrin; Oualha, Mehdi; Özçelık, Tayfun; Pan‐Hammarström, Qiang; Parizot, Christophe; Pascreau, Tiffany; Paz‐Artal, Estela; Pellegrini, Sandra; Pérez de Diego, Rebeca; Philippe, Aurélien; Philippot, Quentin; Planas‐Serra, Laura; Ploin, Dominique; Poissy, Julien; Poncelet, Géraldine; Pouletty, Marie; Quentric, Paul; Raoult, Didier; Rebillat, Anne‐Sophie; Reisli, İsmail; Ricart, Pilar; Richard, Jean‐Christophe; Rivet, Nadia; G. Rivière, Jacques; Rocamora Blanch, Gemma; Rodrigo, Carlos; Rodríguez‐Gallego, Carlos; Rodríguez‐Palmero, Agustí; S. Romero, Carolina; Rothenbühler, Anya; Rozenberg, Flore; Yolanda Ruiz del Prado, María; Sabater‐Riera, Joan; Sanchez, Oliver; Sánchez‐Ramón, Silvia; Schlüter, Agatha; Schmidt, Matthieu; Schweitzer, Cyril; Scolari, Francesco; Šedivá, Anna; Seijó, Luis; Sène, D.; Şenoğlu, Sevtap; Seppänen, Mikko; Serra Ilovich, Alex; Shahrooei, Mohammad; Slabbynck, Hans; M. Smadja, David; Sobh, Ali; Solanich Moreno, Xavier; Solé‐Violán, Jordi; Soler, Catherine; Soler‐Palacín, Pere; Stepanovskiy, Yuri; Stoclin, Annabelle; Silvio Taccone, Fabio; Tandjaoui-Lambiotte, Yacine; Taupin, Jean‐Luc; J. Tavernier, Simon; Terrier, Benjamin; Thumerelle, C.; Tomasoni, Gabriele; Toubiana, Julie; Trenado Alvarez, Josep; Trouillet‐Assant, Sophie; Troya, Jesús; Tucci, Alessandra; Valeria Ursini, Matilde; Uzunhan, Y.; Vabres, P.; Valencia-Ramos, Juan; Van Braeckel, Eva; Van de Velde, Stijn; Maria Van Den Rym, Ana; Van Praet, Jens; Vandernoot, Isabelle; Vatansev, Hülya; Vélez-Santamaría, Valentina; Viel, Sébastien; Vilain, Cédric; E. Vilaire, Marie; Vincent, Audrey; Voiriot, Guillaume; Vuotto, Fanny; Yosunkaya, Alper; Edward Young, Barnaby; Yücel, Fatih; Zannad, Faı̈ez; Zatz, Mayana; Bélot, Alexandre; Bôle‐Feysot, Christine; Lyonnet, Stanislas; Masson, Cécile; Nitschké, Patrick; Pouliet, Aurore; Schmitt, Yoann; Torès, Frédéric; Zarhrate, Mohammed; Abel, Laurent; Andréjak, Claire; Angoulvant, François; Bachelet, Delphine; Basmaci, Romain; Behillil, Sylvie; Beluze, Marine; Benkerrou, Dehbia; Bhavsar, Krishna; Bompart, François; Bouadma, Lila; Bouscambert, Maude; Caralp, Mireille; Cervantes-Gonzalez, Minerva; Chair, Anissa; Coelho, Alexandra; Couffignal, Camille; Couffin-Cadièrgues, Sandrine; D’Ortenzio, Éric; Da Silveira, Charlène; Debray, Marie‐Pierre; Deplanque, Dominique; Descamps, Diane; Desvallées, Mathilde; Diallo, Alpha; Diouf, Alphonsine; Dorival, Céline; Dubos, François; Duval, Xavier; Eloy, Philippine; Enouf, Vincent; Espérou, Hélène; Esposito‐Farèse, Marina; Etienne, Manuel; Ettalhaoui, Nadia; Gault, Nathalie; Gaymard, Alexandre; Ghosn, Jade; Gigante, Tristan; Gorenne, Isabelle; Guedj, Jérémie; Hoctin, Alexandre; Hoffmann, Isabelle; Jaafoura, Salma; Kafif, Ouifiya; Kaguelidou, Florentia; Kali, Sabina; Khalil, Antoine; Khan, Coralie; Laouenan, Cédric; Laribi, Samira; Quan Lê, Minh; Le Hingrat, Quentin; Le Mestre, Soizic; Le Nagard, Hervé; Lescure, François‐Xavier; Lévy, Yves; Lévy‐Marchal, Claire; Lina, Bruno; Lingas, Guillaume; Christophe Lucet, Jean; Malvy, Denis; Mambert, Marina; Mentré, France; Mercier, Noémie; Meziane, Amina; Mouquet, Hugo; Mullaert, Jimmy; Néant, Nadège; Noret, Marion; Pages, Justine; Papadopoulos, Aurélie; Paul, Christelle; Peiffer‐Smadja, Nathan; Petrov–Sanchez, Ventzislava; Peytavin, Gilles; Picone, Olivier; Puéchal, Oriane; Rosa‐Calatrava, Manuel; Rossignol, Bénédicte; Rossignol, Patrick; Roy, Carine; Schneider, Marion; Semaille, Caroline; Si Mohammed, Nassima; Tagherset, Lysa; Tardivon, Coralie; Tellier, Marie-Capucine; Téoulé, François; Terrier, Olivier; Timsit, Jean‐François; Trioux, Théo; Tual, Christelle; Tubiana, Sarah; van der Werf, Sylvie; Vanel, Noémie; Veislinger, Aurélie; Visseaux, Benoît; Wiedemann, Aurélie; Yazdanpanah, Yazdan; Alavoine, Loubna; K. A. Amat, Karine; Behillil, Sylvie; Bielicki, Julia; Bruijning‐Verhagen, Patricia; Burdet, Charles; Caumes, Éric; Charpentier, Charlotte; Coignard, B.; Costa, Yolande; Couffin-Cadièrgues, Sandrine; Damond, Florence; Dechanet, Aline; Delmas, Christelle; Descamps, Diane; Duval, Xavier; Ecobichon, Jean-Luc; Enouf, Vincent; Espérou, Hélène; Frezouls, Wahiba; Houhou, Nadhira; Ilic-Habensus, Emila; Kafif, Ouifiya; Kikoine, John; Le Hingrat, Quentin; Lebeaux, David; Leclercq, Anne; Lehacaut, Jonathan; Letrou, Sophie; Lina, Bruno; Lucet, Jean‐Christophe; Malvy, Denis; Manchon, Pauline; Mandic, Milica; Meghadecha, Mohamed; Motiejūnaitė, Justina; Nouroudine, Mariama; Piquard, Valentine; Postolache, Andreea; Quintin, Caroline; Rexach, Jade; Roufai, Layidé; Terzian, Zaven; Thy, Michaël; Tubiana, Sarah; van der Werf, Sylvie; Vignali, Valérie; Visseaux, Benoît; Yazdanpanah, Yazdan; A. van Agtmael, Michiel; Geke Algera, Anna; van Baarle, Frank; Bax, Diane; Beudel, Martijn; Jan Bogaard, Harm; K. Bomers, Marije; D. J. Bos, Lieuwe; Botta, Michela; de Brabander, Justin; de Bree, Godelieve; C. Brouwer, Matthijs; de Bruin, Sanne; Bugiani, Marianna; Bulle, Esther; Chouchane, Osoul; Cloherty, Alex; Elbers, Paul; M. Fleuren, Lucas; E. Geerlings, Suzanne; F. Geerts, Bart; Geijtenbeek, Theo; R. J. Girbes, Armand; Goorhuis, Bram; P. Grobusch, Martin; Hafkamp, Florianne; A. Hagens, Laura; Hamann, Jörg; Harris, Vanessa; Hemke, Robert; Hermans, Sabine; Heunks, Leo; W. Hollmann, Markus; Horn, Janneke; W. Hovius, Joppe; D. de Jong, Menno; Koning, Rutger; van Mourik, Niels; Nellen, Jeaninne; Paulus, Frederique; J.G. Peters, Edgar; van der Poll, Tom; Preckel, Benedikt; M. Prins, Jan; Raasveld, Jorinde; D. Y. Reijnders, Tom; Schinkel, Michiel; J. Schultz, Marcus; R. Schuurman, Alex; Sigaloff, Kim; R. Smit, Marry; Stijnis, Cornelis; Stilma, Willemke; E. Teunissen, Charlotte; Thoral, Patrick; M. Tsonas, Anissa; van der Valk, Marc; P. Veelo, Denise; P. J. Vlaar, Alexander; de Vries, Heder; van Vugt, Michèle; Joost Wiersinga, W.; Wouters, Dorien; H. Zwinderman, Aeilko; van de Beek, Diederik; Abel, Laurent; Aiuti, Alessandro; Al Muhsen, Saleh; Al‐Mulla, Fahd; S. Anderson, Mark; A. Arias, Andrés; Baris Feldman, Hagit; Bogunovic, Dusan; Bolze, Alexandre; Бондаренко, Анастасія; A. Bousfiha, Ahmed; Brodin, Petter; T. Bryceson, Yenan; D. Bustamante, Carlos; J. Butte, Manish; Casari, Giorgio; Chakravorty, Samya; Christodoulou, John; T. Cirulli, Elizabeth; Condino‐Neto, Antônio; A. Cooper, Megan; L. Dalgard, Clifton; David, Alessia; L. DeRisi, Joseph; Desai, Murkesh; A. Drolet, Beth; Espinosa, Sara; Fellay, Jacques; Flores, Carlos; Luis Franco, José; K. Gregersen, Peter; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; F. Heath, Jim; E. Henrickson, Sarah; W.Y. Hsieh, Elena; Imai, Kohsuke; Itan, Yuval; Karamitros, Timokratis; Kisand, Kai; Ku, Cheng‐Lung; Lau, YL; Ling, Yun; Lucas, C.; Maniatis, Tom; Mansouri, Davoud; Maródi, László; Meyts, Isabelle; D. Milner, Joshua; Mironska, Kristina; H. Mogensen, Trine; Morio, Tomohiro; F. P. Ng, Lisa; D. Notarangelo, Luigi; Novelli, Antonio; Novelli, Giuseppe; O’Farrelly, Cliona; Okada, Satoshi; Özçelık, Tayfun; Pérez de Diego, Rebeca; M. Planas, Anna; Prando, Carolina; Pujol, Aurora; Quintana‐Murci, Lluís; Rénia, Laurent; Renieri, Alessandra; Rodríguez‐Gallego, Carlos; Sancho‐Shimizu, Vanessa; G. Sankaran, Vijay; M. Schiabor Barrett, Kelly; Shahrooei, Mohammed; L. Snow, Andrew; Soler‐Palacín, Pere; N. Spaan, András; G. Tangye, Stuart; E. Turvey, Stuart; M. Furkan Uddin, K.; Uddin, Mohammed; van de Beek, Diederik; E. Vazquez, Sara; C. Vinh, Donald; von Bernuth, Horst; Washington, Nicole; Zawadzki, Paweł; C. Su, Helen; Casanova, Jean-Laurent; Jing, Huie; Tung, Wesley; R. Luthers, Christopher; M. Bauman, Bradly; Shafer, Samantha; Zheng, Lixin; Zhang, Zinan; Kubo, Satoshi; D. Chauvin, Samuel; Meguro, Kazuyuki; Shaw, Elana; J. Lenardo, Michael; Lack, Justin; Karlins, Eric; M. Hupalo, Daniel; K. Rosenberger, J.; Sukumar, Gauthaman; D. Wilkerson, Matthew; Zhang, Xijun

doi:10.1126/science.abd4570

Public

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Published in Science • Sep 24, 2020

Authors:

Qian Zhang

Paul Bastard

Zhiyong Liu

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN respon...

Subject

Coronavirus disease 2019 (COVID-19)

Immunity

2019-20 coronavirus outbreak

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!