Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

Casalino, Lorenzo; Gaieb, Zied; A. Goldsmith, Jory; K. Hjorth, Christy; C. Dommer, Abigail; M. Harbison, Aoife; A. Fogarty, Carl; P. Barros, Emília; C. Taylor, Bryn; S. McLellan, Jason; Fadda, Elisa; E. Amaro, Rommie

doi:10.1021/acscentsci.0c01056

Public

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

Published in ACS Central Science • Sep 23, 2020

Authors:

Lorenzo Casalino

Zied Gaieb

Jory A. Goldsmith

Abstract

-glycans at sites N165 and N234 in modulating the conformational dynamics of the spike's receptor binding domain (RBD), which is responsible for ACE2 recognition. This finding is corroborated by biolayer interferometry experiments, which show that deletion of these glycans through N165A and N234A mu...

Subject

Glycan

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Computational biology

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