PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Liu, Rui; Chen, Youwen; Liu, Guangzhi; Li, Chenxi; Song, Yurong; Cao, Zhiwen; Li, Wen; Hu, Jinghong; Lü, Cheng; Liu, Yuanyan

doi:10.1038/s41419-020-02998-6

Public

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Published in Cell Death and Disease • Sep 24, 2020

Authors:

Rui Liu

Youwen Chen

Guangzhi Liu

Abstract

Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular signal cascades and regulates a variety of cellular processes. PI3Ks are considered significant causes of chemoresistance ...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

GSK-3

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