Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Alejandra Tortorici, M.; Beltramello, Martina; A. Lempp, Florian; Pinto, Dora; V. Dang, Ha; E. Rosen, Laura; McCallum, Matthew; Bowen, John; Minola, Andrea; Jaconi, Stefano; Zatta, Fabrizia; De Marco, Anna; Guarino, Barbara; Bianchi, Siro; J. Lauron, Elvin; Tucker, Heather; Zhou, Jiayi; Peter, Alessia; Havenar-Daughton, Colin; A. Wojcechowskyj, Jason; Brett Case, James; E. Chen, Rita; Kaiser, Hannah; Montiel-Ruiz, Martin; Meury, Marcel; Czudnochowski, Nadine; Spreafico, Roberto; Dillen, Josh; Ng, Cindy; Sprugasci, Nicole; Culap, Katja; Benigni, Fabio; Abdelnabi, Rana; Caroline Foo, Shi-Yan; A. Schmid, Michael; Cameroni, Elisabetta; Riva, Agostino; Gabrieli, Arianna; Galli, Massimo; S. Pizzuto, Matteo; Neyts, Johan; S. Diamond, Michael; W. Virgin, Herbert; Snell, Gyorgy; Corti, Davide; Fink, Katja; Veesler, David

doi:10.1126/science.abe3354

Public

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

Shared by NobleBlocks on Nov 20, 2020 • 12:00 AM UTC

Authors:

M. Alejandra Tortorici

Martina Beltramello

Florian A. Lempp

Abstract

A strong cocktail against SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the trimeric spike protein that decorates the virus and binds the ACE2 receptor. Antibodies against the spike that neutralize viral infection have potential as therapeutics. To...

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