Extensive heterogeneity in somatic mutation and selection in the human bladder

R. J. Lawson, Andrew; Abascal, Federico; H. H. Coorens, Tim; Hooks, Yvette; O’Neill, Laura; Latimer, Calli; Raine, Keiran; A. Sanders, Mathijs; Y. Warren, Anne; T. A. Mahbubani, Krishnaa; Bareham, Bethany; M. Butler, Timothy; M. R. Harvey, Luke; Cagan, Alex; Menzies, Andrew; Moore, Luiza; J. Colquhoun, Alexandra; Turner, William; Thomas, Benjamin; Gnanapragasam, Vincent; Williams, Nicholas; M. Rassl, Doris; Vöhringer, Harald; Zumalave, Sonia; Nangalia, Jyoti; M. C. Tubío, José; Gerstung, Moritz; Saeb-Parsy, Kourosh; R. Stratton, Michael; J. Campbell, Peter; J. Mitchell, Thomas; Martincorena, Iñigo

doi:10.1126/science.aba8347

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Extensive heterogeneity in somatic mutation and selection in the human bladder

Shared by NobleBlocks on Oct 2, 2020 • 12:00 AM UTC

Authors:

Andrew R. J. Lawson

Federico Abascal

Tim H. H. Coorens

Abstract

Genetic profiles of the bladder Depending on the environment of the individual, the human bladder can be exposed to carcinogens as they are flushed through the body. Lawson et al. and Li et al. examined the genetic composition of laser-dissected microbiopsies from normal and cancer cells collected f...

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