Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

Yu, Liming; Dong, Xue; Xue, Xiaodong; Xu, Shu; Zhang, Xu; Xu, Yinli; Wang, Zhishang; Wang, Yang; Gao, Hao; Liang, Yan‐Xiao; Yang, Yang; Wang, Huishan

doi:10.1111/jpi.12698

Public

Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

Published in Journal of Pineal Research • Oct 5, 2020

Authors:

Liming Yu

Xue Dong

Xiaodong Xue

Abstract

Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined. Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects while little is known about...

Subject

Melatonin

Reperfusion injury

Medicine

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