Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.

Yu, Li-Ming; Dong, Xue; Xue, Xiao-Dong; Xu, Shu; Zhang, Xu; Xu, Yin-Li; Wang, Zhi-Shang; Wang, Yang; Gao, Hao; Liang, Yan-Xiao; Yang, Yang; Wang, Hui-Shan

doi:10.1111/jpi.12698

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Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: Role of SIRT6.

Shared by NobleBlocks on Jan 1, 2021 • 12:00 AM UTC

Authors:

Li-Ming Yu

Xue Dong

Xiao-Dong Xue

Abstract

Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined. Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects while little is known about...

Subject

SIRT6

diabetic cardiomyopathy

melatonin membrane receptors

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