Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome

Raj Giri, Khem; de Beaurepaire, Laurence; Jégou, Dominique; Lavy, Margot; Mosser, Mathilde; Dupont, Aurélien; Fleurisson, Romain; Dubreil, Laurence; Collot, Mayeul; Van Endert, Peter; Bach, Jean‐Marie; Mignot, Grégoire; Bösch, Steffi

doi:10.3389/fimmu.2020.01814

Public

Molecular and Functional Diversity of Distinct Subpopulations of the Stressed Insulin-Secreting Cell's Vesiculome

Published in Frontiers in Immunology • Sep 30, 2020

Authors:

Khem Raj Giri

Laurence de Beaurepaire

Dominique Jégou

Abstract

Beta cell failure and apoptosis following islet inflammation have been associated with autoimmune type 1 diabetes pathogenesis. As conveyors of biological active material, extracellular vesicles (EV) act as mediators in communication with immune effectors fostering the idea that EV from inflamed bet...

Subject

Inflammation

Cell biology

Immune system

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