Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Qing, Shuang; Lyu, Chengliang; Zhu, Li; Pan, Chao; Wang, Shuang; Li, Feng; Wang, Jianghua; Yue, Hua; Gao, Xiaoyong; Jia, Rongrong; Wei, Wei; Ma, Guanghui

doi:10.1002/adma.202002085

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Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Published in Advanced Materials • Oct 5, 2020

Authors:

Shuang Qing

Chengliang Lyu

Li Zhu

Abstract

The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming. To overcome the obstacles of antibody-dependent clearanc...

Subject

Tumor microenvironment

Reprogramming

Cancer research

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