CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway.

Y, Deleye; AK, Cotte; SA, Hannou; N, Hennuyer; L, Bernard; B, Derudas; S, Caron; V, Legry; E, Vallez; E, Dorchies; N, Martin; S, Lancel; JS, Annicotte; K, Bantubungi; A, Pourtier; V, Raverdy; F, Pattou; P, Lefebvre; C, Abbadie; B, Staels; JT, Haas; R, Paumelle

doi:10.1074/jbc.ra120.012543

Public

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway.

Shared by NobleBlocks on Oct 9, 2020 • 12:00 AM UTC

Authors:

Deleye Y

Cotte AK

Hannou SA

Abstract

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardi...

Subject

Liver

Cell cycle

lipid metabolism

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