CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

Deleye, Yann; K. Cotte, Alexia; Anissa Hannou, Sarah; Hennuyer, Nathalie; Bernard, Lucie; Derudas, Bruno; Caron, Sandrine; Legry, Vanessa; Vallez, Emmanuelle; Dorchies, Emilie; Martin, Nathalie; Lancel, Steve; Annicotte, Jean‐Sébastien; Bantubungi, Kadiombo; Pourtier, Albin; Raverdy, Violeta; Pattou, François; Lefèbvre, Philippe; Abbadie, Corinne; Staels, Bart; T. Haas, Joel; Paumelle, Réjane

doi:10.1074/jbc.ra120.012543

Public

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

Published in Journal of Biological Chemistry • Oct 9, 2020

Authors:

Yann Deleye

Alexia K. Cotte

Sarah Anissa Hannou

Abstract

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A , the locus encoding for p16INK4a (p16), associated with elevated risk for card...

Subject

AMPK

Beta oxidation

Chemistry

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