Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

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Shared by NobleBlocks on Oct 16, 2020 • 12:00 AM UTC

Authors:

Wioletta Rut

Zongyang Lv

Mikolaj Zmudzinski

Abstract

A multidisciplinary approach yields novel inhibitors and reveals substrate specificity, structure, and mechanisms of CoV-2 PLpro.