Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

W. Kunkle, Brian; A. Schmidt, Michael; Klein, Hans‐Ulrich; C. Naj, Adam; L. Hamilton‐Nelson, Kara; B. Larson, Eric; A. Evans, Denis; L. De Jager, Phil; K. Crane, Paul; D. Buxbaum, Joseph; Ertekin‐Taner, Nilüfer; L. Barnes, Lisa; Daniele Fallin, M.; J. Manly, Jennifer; C.P. Go, Rodney; O. Obisesan, Thomas; Ilyas Kamboh, M.; A. Bennett, David; Hall, Kathleen; Goate, Alison; M. Foroud, Tatiana; R. Martin, Eden; Wang, Li‐San; S. Byrd, Goldie; A. Farrer, Lindsay; L. Haines, Jonathan; D. Schellenberg, Gerard; Mayeux, Richard; A. Pericak‐Vance, Margaret; Reitz, Christiane; L. Abner, Erin; Adams Perrie, M.; Albin Roger, L.; Apostolova Liana, G; Steven, Eschrich; Craig, S; Baldwin Clinton, T.; Barber Robert, C.; Barral, Sandra; Thomas, Gunther; James, T.; Beecham Gary, W.; Bigio Eileen, H.; Thomas, D.; Blacker, Deborah; Boeve Bradley, F.; Bowen James, D.; Boxer, Adam; Burke James, R.; Jeffrey, Morris; Cairns Nigel, J; Cao, Chuanhai; Carlsson Cynthia, M.; Carney Regina, M.; Carrasquillo Minerva, M.; David, Hugh-Jones; Cruchaga, Carlos; Dick, Malcom; W. Dickson, Dennis,; S. Doody, Rachelle; Duara, Ranjan; Faber Kelley, M.; Thomas, Jaya; Kenneth, B.; Fardo David, W.; Martin, Roger; H. Ferris, Steven; Frosch Matthew, P.; Galasko Douglas, R.; Gearing, Marla; Daniel, Hervé; Ghetti, Bernardino; R. Gilbert, John,; Green Robert, C.; John, Harding; Håkonarson, Håkon; Hamilton Ronald, L.; Hardy, John; Harrell Lindy, E.; Lawrence, Steve; Ryan, Mary; Huentelman Matthew, J.; Hulette Christine, M; Jarvik Gail, P.; Jin, Lee‐Way; Karydas, Anna; Katz Mindy, J.; John, S.; Dirk Keene, C.; Kim, Ronald; Kramer Joel, H.; Lah James, J.; Yee Leung, Yuk; Li, Ge; Andrew, Peter; Richard, B.; Lyketsos Constantine, G.; Malamon, John; Daniel, Chammiran; Martiniuk, Frank; Masliah, Eliezer; McCormick Wayne, C.; Susan, M; M Andrew, Nesbit; McDonough, Stefan; Ann., Canfield; Mesulam, Marsel; Miller Bruce, L.; Miller Carol, A.; Montine Thomas, J.; Mukherjee, Shubhabrata; Myers Amanda, J.; Sid, Eric; Olichney John, M.; Parisi Joseph, E.; R. Peskind, Elaine; Pierce, Aimee; Poon Wayne, W.; Potter, Huntington; Qu, Liming; Quinn Joseph, F.; Raj, Ashok; A. Raskind, Murray; Reisberg, ‌Barry; S. Reisch, Joan,; Ringman John, M.; Roberson Erik, D.; Rogaeva, Ekaterina; Rosen Howard, J.; Royall Donald, R.; Sager Mark, A.; Schneider Julie, A.; Lon, Su; Seeley William, W.; A. Small, Scott; A. Sonnen, Joshua,; Spina, Salvatore; St George‐Hyslop, Peter; Robert, Aiko; Tanzi Rudolph, E.; Juan, Caballero; Tsuang Debby, W.; Valladares, Otto; Van Deerlin Vivianna, M.; Badri, Nabeel; Harry, Vanessa; Paul Vonsattel, Jean; Weıntraub, Sandra; Welsh-Bohmer Kathleen, A; W Kirk, C; Williamson, Jennifer; Thomas, SubinVarghese; B. Randall, Linnell; Wu, Chuang‐Kuo; Younkin Steven, G.; Yu, Lei; Yu, Chang‐En; Zhao, Yi; R. Graff‐Radford, Neill; Martinez, Izri; Ayodele, Temitope; W. Logue, Mark; B. Cantwell, Laura; Jean‐Francois, Melissa; Kuzma, Amanda; D. Adams, Lonnie; M. Vance, Jeffery; L. Cuccaro, Michael; Chung, Jaeyoon; Mez, Jesse; L. Lunetta, Kathryn; Jun, Gyungah; L. López, Oscar; C. Hendrie, Hugh; M. Reiman, Eric; W. Kowall, Neil; B. Leverenz, James; A. Small, Scott; I. Levey, Allan; E. Golde, Todd; J. Saykin, Andrew; D. Starks, Takiyah; S. Albert, Marilyn; T. Hyman, Bradley; Petersen, Ronald; Sano, Mary; Wısnıewskı, Thomas; Vassar, Robert; A. Kaye, Jeffrey; W. Henderson, Victor; DeCarli, Charles; M. LaFerla, Frank; B. Brewer, James; L. Miller, Bruce; H. Swerdlow, Russell; J. Van Eldik, Linda; L. Paulson, Henry; Q. Trojanowski, John; C. Chui, Helena; N. Rosenberg, Roger; Craft, Suzanne; J. Grabowski, Thomas; Asthana, Sanjay; C. Morris, John; M. Strittmatter, Stephen; A. Kukull, Walter

doi:10.1001/jamaneurol.2020.3536

Public

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

Published in JAMA Neurology • Oct 19, 2020

Authors:

Brian W. Kunkle

Michael A. Schmidt

Hans‐Ulrich Klein

Abstract

Importance: Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hisp...

Subject

Disease

TREM2

Alzheimer's disease

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