Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials

B. Holcomb, John; E. Moore, Ernest; L. Sperry, Jason; O. Jansen, Jan; A. Schreiber, Martin; J. del Junco, Deborah; C. Spinella, Philip; Sauaia, Angela; Brohi, Karim; M. Bulger, Eileen; P. Cap, Andrew; R. Hess, John; H. Jenkins, Donald; Lewis, Roger; D. Neal, Matthew; D. Newgard, Craig; Pati, Shibani; E. Pusateri, Anthony; Rizoli, Sandro; T. Russell, Robert; Shackelford, Stacy; M. Stein, Deborah; E. Steiner, Marie; E. Wang, Henry; R. Ward, Kevin; P. Young, Pampee

doi:10.1097/sla.0000000000004563

Public

Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials

Published in Annals of Surgery • Oct 15, 2020

Authors:

John B. Holcomb

Ernest E. Moore

Jason L. Sperry

Abstract

OBJECTIVE: To address the clinical and regulatory challenges of optimal primary endpoints for bleeding patients by developing consensus-based recommendations for primary clinical outcomes for pivotal trials in patients within 6 categories of significant bleeding, (1) traumatic injury, (2) intracrani...

Subject

Medicine

Hemorrhagic shock

Intensive care medicine

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