Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

Xiao, Kun; He, Wanxue; Guan, Wei; Hou, Fei; Yan, Peng; Xu, Jianqiao; Zhou, Ting; Liu, Yuhong; Xie, Lixin

doi:10.1038/s41419-020-03034-3

Public

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

Published in Cell Death and Disease • Oct 15, 2020

Authors:

Kun Xiao

Wanxue He

Wei Guan

Abstract

Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study foc...

Subject

Mesenchymal stem cell

Exosome

Cancer research

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