Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

S. Anthonymuthu, Tamil; Y. Tyurina, Yulia; Sun, Wan‐Yang; Mikulska‐Ruminska, Karolina; H. Shrivastava, Indira; A. Tyurin, Vladimir; Behice Serinkan Cinemre, Fatma; H. Dar, Haider; P. VanDemark, Andrew; R. Holman, Theodore; Sadovsky, Yoel; R. Stockwell, Brent; He, Rong‐Rong; Bahar, İvet; Bayır, Hülya; E. Kagan, Valerian

doi:10.1016/j.redox.2020.101744

Public

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

Published in Redox Biology • Oct 16, 2020

Authors:

Tamil S. Anthonymuthu

Yulia Y. Tyurina

Wan‐Yang Sun

Abstract

Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic radical reaction. Ferrostatin-1 (Fer-1), a common f...

Subject

Biology

Programmed cell death

Molecular biology

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