Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

E. Gordon, David; Hiatt, Joseph; Bouhaddou, Mehdi; V. Rezelj, Veronica; Ulferts, Svenja; Braberg, Hannes; S. Jureka, Alexander; Obernier, Kirsten; Z. Guo, Jeffrey; Batra, Jyoti; M. Kaake, Robyn; R. Weckstein, Andrew; W. Owens, Tristan; Gupta, Meghna; Pourmal, Sergei; W. Titus, Erron; Cakir, Merve; Soucheray, Margaret; McGregor, Michael; Cakir, Zeynep; Jang, Gwendolyn; J. O’Meara, Matthew; A. Tummino, Tia; Zhang, Ziyang; Foussard, Helene; Rojc, Ajda; Zhou, Yuan; Kuchenov, Dmitry; Hüttenhain, Ruth; Xu, Jiewei; Eckhardt, Manon; L. Swaney, Danielle; M. Fabius, Jacqueline; Ummadi, Manisha; Tutuncuoglu, Beril; Rathore, Ujjwal; Modak, Maya; Haas, Paige; M. Haas, Kelsey; Zar Chi Naing, Zun; H. Pulido, Ernst; Shi, Ying; Barrio-Hernandez, Inigo; Memon, Danish; Petsalaki, Eirini; Dunham, Alistair; Correa Marrero, Miguel; Burke, David; Koh, Cassandra; Vallet, Thomas; A. Silvas, Jesus; M. Azumaya, Caleigh; Billesbølle, Christian; F. Brilot, Axel; G. Campbell, Melody; Diallo, Amy; Sasha Dickinson, Miles; Diwanji, Devan; Herrera, Nadia; Hoppe, Nick; T. Kratochvil, Huong; Liu, Yanxin; E. Merz, Gregory; Moritz, Michelle; C. Nguyen, Henry; Nowotny, Carlos; Puchades, Cristina; N. Rizo, Alexandrea; Schulze-Gahmen, Ursula; M. Smith, Amber; Sun, Ming; D. Young, Iris; Zhao, Jianhua; Asarnow, Daniel; Biel, Justin; Bowen, Alisa; R. Braxton, Julian; Chen, Jen; M. Chio, Cynthia; Seng Chio, Un; Deshpande, Ishan; Doan, Loan; Faust, Bryan; Flores, Sebastian; Jin, Mingliang; Kim, Kate; L. Lam, Victor; Li, Fei; Li, Junrui; Li, Yen-Li; Li, Yang; Liu, Xi; Lo, Megan; E. Lopez, Kyle; A. Melo, Arthur; R. Moss, Frank; Nguyen, Phuong; Paulino, Joana; Ishwar Pawar, Komal; K. Peters, Jessica; H. Pospiech, Thomas; Safari, Maliheh; Sangwan, Smriti; Schaefer, Kaitlin; V. Thomas, Paul; C. Thwin, Aye; Trenker, Raphael; Tse, Eric; Kin Martin Tsui, Tsz; Wang, Feng; Whitis, Natalie; Yu, Zanlin; Zhang, Kaihua; Zhang, Yang; Zhou, Fengbo; Saltzberg, Daniel; Structural Biology Consortium, QCRG; J. Hodder, Anthony; S. Shun-Shion, Amber; M. Williams, Daniel; M. White, Kris; Rosales, Romel; Kehrer, Thomas; Miorin, Lisa; Moreno, Elena; H. Patel, Arvind; Rihn, Suzannah; M. Khalid, Mir; Vallejo-Gracia, Albert; Fozouni, Parinaz; R. Simoneau, Camille; L. Roth, Theodore; Wu, David; Anisul Karim, Mohd; Ghoussaini, Maya; Dunham, Ian; Berardi, Francesco; Weigang, Sebastian; Chazal, Maxime; Park, Jisoo; Logue, James; McGrath, Marisa; Weston, Stuart; Haupt, Robert; James Hastie, C.; Elliott, Matthew; Brown, Fiona; A. Burness, Kerry; Reid, Elaine; Dorward, Mark; Johnson, Clare; G. Wilkinson, Stuart; Geyer, Anna; M. Giesel, Daniel; Baillie, Carla; Raggett, Samantha; Leech, Hannah; Toth, Rachel; Goodman, Nicola; C. Keough, Kathleen; L. Lind, Abigail; Consortium, Zoonomia; J. Klesh, Reyna; R. Hemphill, Kafi; Carlson-Stevermer, Jared; Oki, Jennifer; Holden, Kevin; Maures, Travis; S. Pollard, Katherine; Sali, Andrej; A. Agard, David; Cheng, Yifan; S. Fraser, James; Frost, Adam; Jura, Natalia; Kortemme, Tanja; Manglik, Aashish; R. Southworth, Daniel; M. Stroud, Robert; R. Alessi, Dario; Davies, Paul; B. Frieman, Matthew; Ideker, Trey; Abate, Carmen; Jouvenet, Nolwenn; Kochs, Georg; Shoichet, Brian; Ott, Melanie; Palmarini, Massimo; M. Shokat, Kevan; García-Sastre, Adolfo; A. Rassen, Jeremy; Grosse, Robert; S. Rosenberg, Oren; A. Verba, Kliment; F. Basler, Christopher; Vignuzzi, Marco; A. Peden, Andrew; Beltrao, Pedro; J. Krogan, Nevan

doi:10.1126/science.abe9403

Public

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Shared by NobleBlocks on Dec 4, 2020 • 12:00 AM UTC

Authors:

David E. Gordon

Joseph Hiatt

Mehdi Bouhaddou

Abstract

How lethal coronaviruses engage hosts Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work...

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