Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Cantuti‐Castelvetri, Ludovico; Ojha, Ravi; D. Pedro, Liliana; Djannatian, Minou; Franz, Jonas; Kuivanen, Suvi; van der Meer, Franziska; Kallio, Katri; Kaya, Tuğberk; Anastasina, Maria; Smura, Teemu; Levanov, Lev; Szirovicza, Leonóra; Tobi, Allan; Kallio‐Kokko, Hannimari; Österlund, Pamela; Joensuu, Merja; A. Meunier, Frédéric; J. Butcher, Sarah; Sebastian Winkler, Martin; Mollenhauer, Brit; Helenius, Ari; Gökçe, Özgün; Teesalu, Tambet; Hepojoki, Jussi; Vapalahti, Olli; Stadelmann, Christine; Balistreri, Giuseppe; Simons, Mikael

doi:10.1126/science.abd2985

Public

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Published in Science • Oct 20, 2020

Authors:

Ludovico Cantuti‐Castelvetri

Ravi Ojha

Liliana D. Pedro

Abstract

Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their tissue tropism differs, raising...

Subject

Furin

Tropism

Neuropilin 1

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