A large-scale genome-wide association study meta-analysis of cannabis use disorder

C. Johnson, Emma; Ew, Johnson; Demontis, Ditte; E. Thorgeirsson, Thorgeir; K Walters, Raymond; Polimanti, Renato; S Hatoum, Alexander; Sanchez‐Roige, Sandra; E. Paul, Sarah; R. Wendt, Frank; Clarke, Toni-Kim; Lai, Dongbing; W. Reginsson, Gunnar; J Zhou, H; He, June; A A Baranger, David; Df, Gudbjartsson; Wedow, Robbee; Adkins, Amy; Adkins, Amy; Alexander, Jeffry; Bacanu, Silviu‐Alin; B Bigdeli, T; Boden, Joseph; A Brown, Sandra; K. Bucholz, Kathleen; Bybjerg‐Grauholm, Jonas; P Corley, Robin; Degenhardt, L; M Dick, Danielle; W. Domingue, Benjamin; Fox, Louis; M Goate, Alison; D. Gordon, Scott; M. Hack, Laura; B Hancock, D; M. Hartz, Sarah; Hickie, I; Dm, Hougaard; Krauter, Kenneth; A Lind, Penelope; N. McClintick, Jeanette; B McQueen, Matthew; L Meyers, Jacquelyn; W Montgomery, Grant; Mors, Ole; B Mortensen, Preben; Nordentoft, Merete; F. Pearson, John; E Peterson, Roseann; Reynolds, Maureen; P Rice, John; Rúnarsdóttir, Valgerður; L Saccone, Nancy; Sherva, R; L. Silberg, Judy; E Tarter, Ralph; Tyrfingsson, Þórarinn; L. Wall, Tamara; T Webb, Bradley; Tm, Werge; Wetherill, Leah; J. Wright, Margaret; Zellers, Stephanie; J. Adams, Mark; J Bierut, Laura; D Boardman, Jason; E Copeland, William; A Farrer, Lindsay; M Foroud, Tatiana; A Gillespie, Nathan; A. Grucza, Richard; KM, Harris; C Heath, Andrew; Hesselbrock, Victor; K. Hewitt, John; J. Hopfer, Christian; Horwood, John; G Iacono, W; Ew, Johnson; Ew, Johnson; Ks, Kendler; A. Kennedy, Martin; R Kranzler, Henry; A F Madden, P; H Maes, Hermine; S Maher, Brion; Martín, Nuria; McGue, Matthew; C McINTOSH, A; E Medland, S; C Nelson, Elliot; Porjesz, Bernice; P. Riley, Brien; C. Stallings, Michael; M. Vanyukov, Michael; Vrieze, Scott; Walters, Raymond; Polimanti, Renato; Ew, Johnson; Ew, Johnson; McClintick, Jeanette; Hatoum, Alexander; He, June; Wendt, Frank; J Zhou, H; Adams, Mark; Adkins, Amy; Aliev, Fazil; Bacanu, Silviu‐Alin; Batzler, Anthony; Bertelsen, S; Biernacka, Joanna; Bigdeli, Tim; Chen, Li-Shiun; Clarke, Toni-Kim; Chou, Yi-Ling; Degenhardt, Franziska; Docherty, Anna; Am, Edwards; Fontanillas, Pierre; Foo, Jerome; Fox, Louis; Frank, Josef; Giegling, Ina; Gordon, Scott; Hack, Laura; Hartmann, Annette; Hartz, Sarah; Heilmann-Heimbach, Stefanie; Herms S, Pérez; Hodgkinson, Colin; Hoffman, Per; Hottenga, Jouke; Kennedy, Martin; Alanne-Kinnunen, Mervi; Konte, Bettina; Lahti, Jari; Lahti-Pulkkinen, Marius; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion; Mbarek, Hamdi; McIntosh, Andrew; McQueen, Matthew; Meyers, Jacquelyn; Milaneschi, Yuri; Palviainen, Teemu; Pearson, John; Peterson, Roseann; Ripatti, S; Ryu, Euijung; Saccone, Nancy; Salvatore, Jessica; Sanchez‐Roige, Sandra; Schwandt, Melanie; Sherva, R; Streit, Fabian; Strohmaier, J; Thomas, Nathaniel; Wang, Jen-Chyong; Webb, Bradley; Wedow, Robbee; Wetherill, Leah; Wills, Amanda; Boardman, Jason; Chen, Danfeng; Choi, Doo-Sup; Copeland, William; Culverhouse, Robert; Dahmen, Norbert; Degenhardt, L; Domingue, Benjamin; Elson, Sarah; Frye, Mark; Gäbel, Wolfgang; Hayward, Caroline; Ising, M; Keyes, Margaret; Kiefer, F; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael; Maier, Wolfgang; Mann, Karl; Männistö, Satu; Müller‐Myhsok, Bertram; Murray, Alison; Nurnberger, John; Palotie, Aarno; Preuss, Ulrich; Räikkönen, Katri; Reynolds, Maureen; Ridinger, Monika; Scherbaum, N; Schuckit, Marc; B Soyka, M; Treutlein, Jens; Witt, Stephanie; Wodarz, Norbert; Zill, Peter; Adkins, Daniel; Boden, Joseph; Boomsma, Dorret; Bierut, Laura; M Brown, S; Bucholz, Kathleen; Cichon, Sven; J. Costello, E.; de Wit, Harriet; Diazgranados, Nancy; Dick, Danielle; Eriksson, Johan; Farrer, Lindsay; Foroud, Tatiana; Gillespie, Nathan; Goate, Alison; Goldman, David; Grucza, Richard; Hancock, Dana; KM, Harris; Heath, Andrew; Hesselbrock, Victor; Jk, Hewitt; Hopfer, Christian; Horwood, John; G Iacono, W; Ew, Johnson; Ew, Johnson; Kaprio, Jaakko; Karpyak, Victor; Ks, Kendler; Kranzler, Henry; Krauter, Kenneth; Lichtenstein, Paul; Lind, Penelope; McGue, M; MacKillop, James; Madden, Pamela; Maes, Hermine; Magnusson, Patrik; Martín, Nuria; E Medland, S; Montgomery, G.; Nelson, Elliot; Nöthen, Markus; palmer, abraham; Pederson, Nancy; penninx, brenda; Porjesz, Bernice; Rice, John; Rietschel, M; Riley, B; Rose, Richard; Rujescu, D; Shen, Pei‐Hong; Silberg, Judy; Stallings, Michael; Tarter, Ralph; Vanyukov, Michael; Vrieze, Scott; Wall, Tamara; Whitfield, John; Zhao, Hongyu; Neale, Benjamin; Gelernter, J; Edenberg, Howard; Agrawal, Arpana; K Davis, Lea; Bogdan, Ryan; Gelernter, J; J. Edenberg, Howard; Stefánsson, Kāri; D. Børglum, Anders; Agrawal, Arpana

doi:10.1016/s2215-0366(20)30339-4

Public

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Published in The Lancet Psychiatry • Oct 20, 2020

Authors:

Emma C. Johnson

Johnson Ew

Ditte Demontis

Abstract

BACKGROUND: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association ...

Subject

Meta-analysis

Genome-wide association study

Cannabis

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