Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Gupta, Shruti; Wang, Wei; S. Hayek, Salim; Chan, Lili; S. Mathews, Kusum; L. Melamed, Michal; K. Brenner, Samantha; K. Leonberg‐Yoo, Amanda; J. Schenck, Edward; Radbel, Jared; Reiser, Jochen; Bansal, Anip; Srivastava, Anand; Zhou, Yan; G. Finkel, Diana; Green, Adam; C. Mallappallil, Mary; J. Faugno, Anthony; Zhang, Jingjing; Carlos Q. Velez, Juan; Shaefi, Shahzad; R. Parikh, Chirag; M. Charytan, David; M. Athavale, Ambarish; N. Friedman, Allon; E. Redfern, Roberta; Short, Samuel; Correa, Simon; K. Pokharel, Kapil; J. Admon, Andrew; P. Donnelly, John; B. Gershengorn, Hayley; J. Douin, David; W. Semler, Matthew; A. Hernán, Miguel; E. Leaf, David; Investigators, STOP-COVID; P. Walther, Carl; J. Anumudu, Samaya; Arunthamakun, Justin; F. Kopecky, Kathleen; P. Milligan, Gregory; A. McCullough, Peter; Nguyen, Thuy-Duyen; Shaefi, Shahzad; L. Krajewski, Megan; Shankar, Sidharth; Pannu, Ameeka; D. Valencia, Juan; S. Waikar, Sushrut; A. Kibbelaar, Zoé; M. Athavale, Ambarish; C. Hart, Peter; Upadhyay, Shristi; Vohra, Ishaan; Ajiboye, Oyintayo; Green, Adam; Rachoin, Jean-Sébastien; Schorr, Christa; Shea, Lisa; Edmonston, Daniel; L. Mosher, Christopher; M. Shehata, Alexandre; Cohen, Zaza; Allusson, Valerie; Bambrick‐Santoyo, Gabriela; ul aain Bhatti, Noor; Mehta, Bijal; Williams, Aquino; K. Brenner, Samantha; Walters, Patricia; C. Go, Ronaldo; Rose, Keith; A. Hernán, Miguel; Lisk, Rebecca; M. Zhou, Amy; C. Kim, Ethan; Chan, Lili; S. Mathews, Kusum; G. Coca, Steven; R. Altman, Deena; Saha, Aparna; Soh, Howard; Hsun Wen, Huei; Bose, Sonali; Leven, Emily; G. Wang, Jing; Mosoyan, Gohar; N. Nadkarni, Girish; Pattharanitima, Pattharawin; J. Gallagher, Emily; N. Friedman, Allon; Guirguis, John; Kapoor, Rajat; Meshberger, Christopher; J. Kelly, Katherine; R. Parikh, Chirag; T. Garibaldi, Brian; P. Corona‐Villalobos, Celia; Wen, Yumeng; Menez, Steven; F. Malik, Rubab; Elena Cervantes, C.; C. Gautam, Samir; C. Mallappallil, Mary; Ouyang, Jie; John, Sabu; Yap, Ernie; Adama Melaku, Yohannes; Mohamed, Ibrahim; Bajracharya, Siddhartha; Puri, Isha; Thaxton, Mariah; Bhattacharya, Jyotsna; E. Wagner, John; Boudourakis, Leon; Bryant Nguyen, H.; Ahoubim, Afshin; Kashani, Kianoush; Tehranian, Shahrzad; F. Thomas, Leslie; Reddy Sirganagari, Dheeraj; Guru, Pramod; Zhou, Yan; A. Bergl, Paul; Rodríguez, Jesús; A. Shah, Jatan; S. Gupta, Mrigank; Kumar, Princy; G. Lazarous, Deepa; Kassaye, Seble; L. Melamed, Michal; S. Johns, Tanya; Mocerino, Ryan; Prudhvi, Kalyan; Zhu, Denzel; V. Levy, Rebecca; Azzi, Yorg; Fisher, Molly; Yunes, Milagros; Sedaliu, Kaltrina; Golestaneh, Ladan; Brogan, Maureen; Kumar, Neelja; Chang, Michael; Thakkar, Jyotsana; Raichoudhury, Ritesh; Athreya, Akshay; Farag, Mohamed; J. Schenck, Edward; Jung Cho, Soo; Plataki, Maria; Alvarez-Mulett, Sergio; G. Gómez-Escobar, Luis; Pan, Di; Lee, Stefi; K. Krishnan, Jamuna; Whalen, William; M. 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Neyra, Javier; Chaaban, Nourhan; Elias, Madona; Ahmad, Yahya; Iardino, Alfredo; H. Au, Elizabeth; H. Sharma, Jill; Anne Sosa, Marie; Taldone, Sabrina; Contreras, Gabriel; De La Zerda, David; Fornoni, Alessia; B. Gershengorn, Hayley; S. Hayek, Salim; Blakely, Pennelope; Berlin, Hanna; U. Azam, Tariq; Shadid, Husam; Pan, Michael; O’ Hayer, Patrick; Meloche, Chelsea; Feroze, Rafey; Padalia, Kishan; Bitar, Abbas; Leya, Jeff; P. Donnelly, John; J. Admon, Andrew; E. Flythe, Jennifer; J. Tugman, Matthew; Chang, Emily; R. Brown, Brent; K. Leonberg‐Yoo, Amanda; Spiardi, Ryan; A. Miano, Todd; S. Roche, Meaghan; R. Vasquez, Charles; D. Bansal, Amar; C. Ernecoff, Natalie; Kapoor, Sanjana; Verma, Siddharth; Chen, Huiwen; P. Kövesdy, Csaba; Z. Molnar, Miklos; Azhar, Ambreen; Susan Hedayati, S.; Nadamuni, Mridula; Shastri, Shani; L. Willett, DuWayne; Short, Samuel; D. Renaghan, Amanda; B. Enfield, Kyle; K. Bhatraju, Pavan; Malik, Adeel; W. Semler, Matthew; Vijayan, Anitha; Mariyam Joy, Christina; Li, Tingting; Goldberg, Seth; F. Kao, Patricia; Schumaker, Greg; Goyal, Nitender; J. Faugno, Anthony; M. Hsu, Caroline; Tariq, Asma; Meyer, Leah; K. Kshirsagar, Ravi; Jose, Aju; E. Weiner, Daniel; Christov, Marta; Griffiths, Jennifer; Gupta, Sanjeev; Kapoor, Aromma; Wilson, Perry; Arora, Tanima; Ugwuowo, Ugochukwu

doi:10.1001/jamainternmed.2020.6252

Public

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Published in JAMA Internal Medicine • Oct 20, 2020

Authors:

Shruti Gupta

Wei Wang

Salim S. Hayek

Abstract

Importance: Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract the inflammatory cytokine release syndrome in patients with severe COVID-19 illness. Objec...

Subject

Tocilizumab

Medicine

Coronavirus disease 2019 (COVID-19)

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