CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

Corgnac, Stéphanie; Malenica, Ines; Mezquita, Laura; Auclin, Édouard; Voilin, Elodie; Kacher, Jamila; M. Halse, Heloise; Grynszpan, Laetitia; Signolle, Nicolas; Dayris, Thibault; Leclerc, Marine; Droin, Nathalie; de Montpréville, Vincent; Mercier, Olaf; Validire, Pierre; Scoazec, Jean‐Yves; Massard, Christophe; Chouaı̈b, Salem; Planchard, David; Adam, Julien; Besse, Benjamin; Mami‐Chouaib, Fathia

doi:10.1016/j.xcrm.2020.100127

Public

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

Published in Cell Reports Medicine • Oct 1, 2020

Authors:

Stéphanie Corgnac

Ines Malenica

Laura Mezquita

Abstract

Accumulation of CD103 + CD8 + resident memory T (T RM ) cells in human lung tumors has been associated with a favorable prognosis. However, the contribution of T RM to anti-tumor immunity and to the response to immune checkpoint blockade has not been clearly established. Using quantitative multiplex...

Subject

CD8

Immunotherapy

Lung cancer

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