Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

Hermine, Olivier; Mariette, Xavier; Tharaux, Pierre‐Louis; Resche‐Rigon, Matthieu; Porcher, Raphaël; Ravaud, Philippe; Collaborative Group, CORIMUNO-19; Bureau, Serge; Dougados, Maxime; Tibi, Annick; Azoulay, Élie; Cadranel, Jacques; Emmerich, Joseph; Fartoukh, Muriel; Guidet, Bertrand; Humbert, Marc; Lacombe, Karine; Mahévas, Matthieu; Pène, Frédéric; Pourchet-Martinez, Valérie; Schlemmer, F.; Yazdanpanah, Yazdan; Baron, Gabriel; Perrodeau, Élodie; Vanhoye, Damien; Kedzia, Cécile; Demerville, Lauren; Gysembergh-Houal, Anne; Bourgoin, Alexandre; Dalibey, Sarah; Resche‐Rigon, Matthieu; Raked, Nabil; Mameri, Lakhdar; Alary, Stéphanie; Hamiria, Samir; Bariz, Thinhinane; Semri, Hala; Meriem Hai, Dhiaa; Benafla, Moustafa; Belloul, Mohamed; Vauboin, Pernelle; Flamand, Saskia; Pacheco, Claire; Walter‐Petrich, Anouk; Ya. 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Chousterman, Benjamin; Mégarbane, Bruno; Richette, Pascal; Riveline, Jean‐Pierre; Frazier, Aline; Vicaut, Éric; Berton, Laure; Hadjam, Tassadit; Alejandro Vasquez-Ibarra, Miguel; Jourdaine, Clément; Jacob, Aude; Smati, Julie; Renaud, Stéphane; Manivet, Philippe; Pernin, Claire; Suarez, Lydia; Semerano, Luca; Abad, S.; Benaïnous, Ruben; Bloch Queyrat, Coralie; Bonnet, Nicolas; Brahmi, Sabrina; Cailhol, Johann; Cohen, Yves; Comparon, Céline; Cordel, Hugues; Dhôte, Robin; Dournon, Nathalie; Duchemann, Boris; Ebstein, Nathan; Giroux-Leprieur, B.; Goupil de Bouillé, Jeanne; Jacolot, Anne; Nunès, Hilario; Oziel, Johanna; Rathouin, Vanessa; Rigal, Marthe; Roulot, Dominique; Tantet, Claire; Uzunhan, Y.; Costedoat-Chalumeau, Nathalie; Ait Hamou, Zakaria; Benghanem, Sarah; Blanche, P.; Canouï, Étienne; Carlier, Nicolas; Chaigne, Benjamin; Contejean, Adrien; Dunogué, Bertrand; Dupland, Pierre; Durel - Maurisse, Aurélie; Gauzit, R.; Jaubert, Paul; Joumaa, Hassan; Jozwiak, Mathieu; Kernéis, Solen; Lachâtre, Marie; Lafoeste, Hélène; Legendre, Paul; Binh Luong Nguyen, Liêm; Marey, Jonathan; Morbieu, Caroline; Mouthon, Luc; S. Nguyen, Lee; Palmieri, Lola‐Jade; Régent, Alexis; Szwebel, Tali‐Anne; Terrier, Benjamin; Guérin, Corinne; Zerbit, Jérémie; Cheref, Kahina; Chitour, Kamil; Salif Cisse, Mamadou; Clarke, Ada; Clavere, Gaëlle; Dusanter, Isabelle; Gaudefroy, Caroline; Jallouli, M.; Kolta, S.; Le Bourlout, Catherine; Marin, Nathalie; Menage, Nathalie; Moores, Alexandre; Peigney, Isabelle; Pierron, Cédric; Saleh-Mghir, Samira; Vallet, Mathilde; Michel, Marc; Melica, Giovanna; Lelievre, Jean-Daniel; Foïs, Eléna; Lim, Pascal; Matignon, Marie; Guillaud, Constance; Thiemele, Alaki; Schmitz, David; Bouhris, Marion; Belazouz, Syllia; Languille, Laetitia; Mekontso-Dessaps, Armand; Sadaoui, Thiziri; Mayaux, Julien; Cacoub, P.; Corvol, Jean‐Christophe; Louapre, Céline; Sambin, Sara; Mariani, Louise‐Laure; Karachi, Carine; Tubach, Florence; Estellat, Candice; Gimeno, Linda; Martin, Karine; Bah, Aïcha; Keo, Vixra; Ouamri, Sabrine; Messaoudi, Yasmine; Yelles, Nessima; Faye, Pierre; Cavelot, Sébastien; Larcheveque, Cecile; Annonay, Laurence; Benhida, Jaouad; Zahrate-Ghoul, Aida; Hammal, Soumeya; Belilita, Ridha; Lecronier, Marie; Beurton, Alexandra; Haudebourg, Luc; Déléris, Robin; Le Marec, Julien; Virolle, Sara; Nemlaghi, Safaa; Bureau, Côme; Mora, Pierre; De Sarcus, Martin; Clovet, Olivier; Duceau, Baptiste; Henri Grisot, Paul; Hélène Pari, Marie; Arzoine, Jérémy; Clarac, Ulrich; Faure, Morgane; Delemazure, Julie; Decavèle, Maxence; Morawiec, Élise; Demoule, Alexandre; Dres, Martin; Vautier, Mathieu; Allenbach, Yves; Benvéniste, Olivier; Leroux, Gaëlle; Rigolet, Aude; Guillaume-Jugnot, Perrine; Domont, F.; Desbois, A.C.; Comarmond, Cloé; Champtiaux, Nicolas; Toquet, S.; Ghembaza, Amine; Vieira, Matheus; Maalouf, Georgina; Boleto, Gonçalo; Ferfar, Yasmina; Charbonnier, Fanny; Aguilar, Claire; Alby‐Laurent, Fanny; Alyanakian, Marie‐Alexandra; Bakouboula, Prissile; Broissand, Christine; Burger, Carole; Campos-Vega, Clara; Chavarot, Nathalie; Choupeaux, Laure; Elie, Caroline; Fournier, Benjamin; Granville, Sophie; Issorat, Elodie; Rouzaud, Claire; Vimpère, Damien; Géri, Guillaume; Derridj, Nawal; Sguiouar, Naima; Meddah, Hakim; Djadel, Mourad; Chambrin-Lauvray, Hélène; Duclos‐Vallée, Jean‐Charles; Saliba, Faouzi; Sacleux, Sophie‐Caroline; Koumis, Ilias; Michot, Jean‐Marie; Stoclin, Annabelle; Colomba, Émeline; Pommeret, Fanny; Willekens, Chistophe; da Silva, Rosa; Dejean, Valérie; Mekid, Yasmina; Ben-Mabrouk, Ines; Pradon, Caroline; Drouard, Laurence; Camara‐Clayette, Valérie; Morel, Alexandre; Garcia, Gilles; Mohebbi, Abolfazl; Berbour, Férial; Dehais, Mélanie; Pouliquen, Anne-Lise; Klasen, Alison; Soyez-Herkert, Loren; London, Jonathan; Keroumi, Younes; Guillot, Emmanuelle; Grailles, Guillaume; El Amine, Younes; Defrancq, Fanny; Fodil, Hanane; Bouras, Chaouki; Dautel, Dominique; Gambier, Nicolas; Dieye, Thierno; Bienvenu, Boris; Lançon, Victor; Lecomte, Laurence; Beziriganyan, Kristina; Asselate, Belkacem; Allanic, Laure; Kiouris, Eléna; Legros, Marie-Hélène; Lemagner, Christine; Martel, Pascal; Provitolo, Vincent; Ackermann, Félix; Marchand, Mathilde; Clan Hew Wai, Aurélie; Frémont, Dimitri; Coupez, Elisabeth; Adda, Mireille; Duee, Frédéric; Bernard, Lise; Gros, Antoine; Henry, Estelle; Courtin, Claire; Pattyn, Anne; Guinot, Pierre‐Grégoire; Bardou, Marc; Maurer, Agnès; Jambon, Julie; Cransac, Amélie; Pernot, C; Mourvillier, Bruno; Servettaz, Amélie; Deslée, Gaëtan; Wynckel, Alain; Benoit, P; Marquis, Eric; Roux, Damien; Gernez, Coralie; Yelnik, Cécile; Poissy, Julien; Nizard, Mandy; Deniès, Fanette; Gros, Hélène; Mourad, Jean‐Jacques; Sacco, Emmanuelle; Renet, Sophie

doi:10.1001/jamainternmed.2020.6820

Public

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

Published in JAMA Internal Medicine • Oct 20, 2020

Authors:

Olivier Hermine

Xavier Mariette

Pierre‐Louis Tharaux

Abstract

Importance: Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). Objective: To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia. Design, Setting, an...

Subject

Medicine

Tocilizumab

Pneumonia

Research Assistant

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