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                    ‑Trifluoromethyl Amines and
Azoles: An Underexplored Functional Group in the Medicinal Chemist’s
Toolbox

Schiesser, Stefan; Chepliaka, Hanna; Kollback, Johanna; Quennesson, Thibaut; Czechtizky, Werngard; J. Cox, Rhona

doi:10.1021/acs.jmedchem.0c01457

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N ‑Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist’s Toolbox

Shared by NobleBlocks on Oct 28, 2020 • 12:00 AM UTC

Authors:

Stefan Schiesser

Hanna Chepliaka

Johanna Kollback

Abstract

Abstract Introducing trifluoromethyl groups is a common strategy to improve the properties of biologically active compounds. However, N-trifluoromethyl moieties on amines and azoles are very rarely used. To evaluate their suitability in drug design, we synthesized a series of N-trifluoromethyl amine...

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