SARS-CoV-2 viral load is associated with increased disease severity and mortality

Fajnzylber, Jesse; Regan, James; Coxen, Kendyll; Corry, Heather; Wong, Colline; Rosenthal, Alexandra; Worrall, Daniel; Giguel, Françoise; Piechocka‐Trocha, Alicja; Atyeo, Caroline; Fischinger, Stephanie; T. Chan, Andrew; T. Flaherty, Keith; Hall, Kathryn; Dougan, Michael; T. Ryan, Edward; Gillespie, Elizabeth; Chishti, Rida; Li, Yijia; Jilg, Nikolaus; Hanidziar, Dusan; M. Baron, Rebecca; R. Baden, Lindsey; Tsibris, Athe; Armstrong, Katrina; R. Kuritzkes, Daniel; Alter, Galit; D. Walker, Bruce; G. Yu, Xu; Z. Li, Jonathan; A. Abayneh, Betelihem; Allen, Patrick; Antille, Diane; B. Balazs, Alejandro; Bals, Julia; Barbash, Max; C. Bartsch, Yannic; Boucau, Julie; Boyce, Siobhan; Braley, Joan; Branch, Karen; Broderick, Katherine; Carney, Julia; M Chevalier, Joshua; C. Choudhary, Manish; Chowdhury, Navin; Cordwell, Trevor; Q. Daley, George; Davidson, Susan; Desjardins, Michaël; Donahue, Lauren; A. Drew, David; Einkauf, Kevin; Elizabeth, Sampson; Elliman, Ashley; Etemad, Behzad; Fallon, Jon; Fedirko, Liz; Finn, Kelsey; Flannery, Jeanne; J. Forde, Pamela; García‐Broncano, Pilar; Gettings, Elise; Golan, David; Goodman, Kirsten; Griffin, Amanda; Grimmel, Sheila; Grinke, Kathleen; Adijaya Hartana, Ciputra; Healy, Meg; M. Heller, Howard; Henault, Deborah; Holland, Grace; Jiang, Chenyang; Jordan, Hannah; Kapłonek, Paulina; W. Karlson, Elizabeth; Karpell, Marshall; Kayitesi, Chantal; C. Lam, Evan; LaValle, Vlasta; Lefteri, Kristina; Lian, Xiaodong; Lichterfeld, Mathias; Lingwood, Daniel; Liu, Hang; Liu, Jin-Qing; A. J. Lopez, K.; Lu, Yuting; Luthern, Sarah; L. Ly, Ngoc; MacGowan, Maureen; Magispoc, Karen; Marchewka, Jordan; Martino, Brittani; McNamara, Roseann; R. Michell, Ashlin; Millstrom, Ilan; Miranda, Noah; Nambu, Christian; C. Nelson, Susan; Noone, Marjorie; A. Novack, Lewis; O’Callaghan, Claire; Ommerborn, Christine; R. Osborn, Matthew; Chris Pacheco, Lois; Phan, Nicole; Pillai, Shiv; A. Porto, Falisha; Rassadkina, Yelizaveta; Reissis, Alexandra; F. Ruzicka, Francis; Seiger, Kyra; Selleck, Kathleen; Sessa, Libera; Sharpe, Arlene; Sharr, Christianne; Shin, Sally; K. Singh, Nishant; Slaughenhaupt, Sue; Smith Sheppard, Kimberly; Sun, Weiwei; Sun, Xiaoming; Suschana, Elizabeth; Talabi, Opeyemi; Ticheli, Hannah; T. Weiss, Scott; Wilson, Vivine; Zhu, Alex

doi:10.1038/s41467-020-19057-5

Public

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Published in Nature Communications • Oct 30, 2020

Authors:

Jesse Fajnzylber

James Regan

Kendyll Coxen

Abstract

The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, out...

Subject

Viral load

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

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