Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

Carpinteiro, Alexander; J. Edwards, Michael; Hoffmann, Markus; Kochs, Georg; Gripp, Barbara; Weigang, Sebastian; Adams, Constantin; Carpinteiro, Elisa; Gulbins, Anne; Keitsch, Simone; Sehl, Carolin; Soddemann, Matthias; Wilker, Barbara; Kamler, Markus; Bertsch, Thomas; S. Lang, Karl; H. Patel, Sameer; C. Wilson, Gregory; Walter, Silke; Hengel, Hartmut; Pöhlmann, Stefan; A. Lang, Philipp; Kornhuber, Johannes; Anne Becker, Katrin; A. Ahmad, Syed; Faßbender, Klaus; Gulbins, Erich

doi:10.1016/j.xcrm.2020.100142

Public

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

Published in Cell Reports Medicine • Oct 30, 2020

Authors:

Alexander Carpinteiro

Michael J. Edwards

Markus Hoffmann

Abstract

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the e...

Subject

Ceramide

Acid sphingomyelinase

Sphingomyelin phosphodiesterase

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!