TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Tang, Qiang; Chen, Jinhuang; Di, Ziyang; Yuan, Wenzheng; Zhou, Zili; Liu, Zhengyi; Han, Shengbo; Liu, Yanwei; Ying, Guoguang; Shu, Xiaogang; Di, Maojun

doi:10.1186/s13046-020-01690-z

Public

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Published in Journal of Experimental & Clinical Cancer Research • Nov 5, 2020

Authors:

Qiang Tang

Jinhuang Chen

Ziyang Di

Abstract

BACKGROUND: Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of TM4SF1 and its potential mechanism in colorectal cancer (CRC) remain elusive. METHODS: We investigated the expression of TM4SF1 ...

Subject

Wnt signaling pathway

Cancer research

Epithelial–mesenchymal transition

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