Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

W. Ng, Kevin; Faulkner, Nikhil; H. Cornish, Georgina; Rosa, Annachiara; Harvey, Ruth; Hussain, Saira; Ulferts, Rachel; Earl, Christopher; G. Wrobel, Antoni; Benton, D.J.; Roustan, Chloë; Bolland, William; Houston Thompson, R.; Agua‐Doce, Ana; Hobson, Philip; Heaney, Judith; M. Rickman, Hannah; Paraskevopoulou, Stavroula; Houlihan, Catherine; Thomson, Kirsty; Sanchez, Emilie; Yen Shin, Gee; Spyer, Moira; Joshi, Dhira; O’Reilly, Nicola; Walker, P.A.; Kjær, Svend; Riddell, Andrew; Moore, Catherine; R. Jebson, Bethany; Wilkinson, Meredyth; Marshall, Lucy; C. Rosser, Elizabeth; Radziszewska, Anna; Peckham, Hannah; Ciurtin, Coziana; R. Wedderburn, Lucy; Beale, Rupert; Swanton, Charles; Gandhi, Sonia; Stockinger, Brigitta; W. McCauley, John; Gamblin, S.J.; E. McCoy, Laura; Cherepanov, Peter; Nastouli, Eleni; Kassiotis, George

doi:10.1126/science.abe1107

Public

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Published in Science • Nov 6, 2020

Authors:

Kevin W. Ng

Nikhil Faulkner

Georgina H. Cornish

Abstract

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable using a flow cytometry-based...

Subject

Antibody

Immunity

Humoral immunity

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