The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

Tang, Bufu; Zhu, Jinyu; Li, Jie; Fan, Kai; Gao, Yang; Cheng, Shimiao; Kong, Chunli; Zheng, Liyun; Wu, Fazong; Weng, Qiaoyou; Lu, Chenying; Ji, Jiansong

doi:10.1186/s12964-020-00663-1

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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

Published in Cell Communication and Signaling • Oct 28, 2020

Authors:

Bufu Tang

Jinyu Zhu

Jie Li

Abstract

BACKGROUND: In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the relationship with the immune microenvironment in HCC. METHODS: Integrated analysis, cox regression and the least absolute shrinkage an...

Subject

Hepatocellular carcinoma

Immune system

Proportional hazards model

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