Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Volz, Erik; Hill, Verity; T. McCrone, John; Price, Anna; Jorgensen, David; O’Toole, Áine; Southgate, Joel; Johnson, Robert; Jackson, Ben; F. Nascimento, Fabrícia; Rey, Sara; M. Nicholls, Samuel; Colquhoun, Rachel; da Silva Filipe, Ana; G. Shepherd, James; J. Pascall, David; Shah, Rajiv; Jesudason, Natasha; Li, Kathy; F. Jarrett, Ruth; Pacchiarini, Nicole; Bull, Matthew; Geidelberg, Lily; Siveroni, Igor; Koshy, Cherian; L. Wise, Emma; Cortes, Nick; Lynch, Jessica; P. Kidd, Stephen; Mori, Matilde; Fairley, Derek; Curran, Tanya; McKenna, James; Adams, Helen; Fraser, Christophe; Golubchik, Tanya; Bonsall, David; E. Moore, Catrin; Caddy, Sarah; Khokhar, Fahad; Wantoch, Michelle; Reynolds, Nicola; Warne, Ben; Maksimovic, Joshua; Spellman, Karla; McCluggage, Kathryn; P.T. Mo, John; Beer, Robert; Afifi, Safiah; Morgan, Siân; Marchbank, Angela; Price, Anna; Kitchen, Christine; Gulliver, Huw; Merrick, Ian; Southgate, Joel; F. Guest, Martyn; J. Munn, Robert; Workman, Trudy; R. Connor, Thomas; Fuller, William; Bresner, Catherine; B. Snell, Luke; Charalampous, Themoula; Nebbia, Gaia; Batra, Rahul; Edgeworth, Jonathan; C. Robson, Samuel; H. Beckett, Angela; F. Loveson, Katie; M. Aanensen, David; P. Underwood, Anthony; Yeats, Corin; Abudahab, Khalil; Taylor, Ben; Menegazzo, Mirko; Clark, Gemma; Smith, Darren; Khakh, Manjinder; M. Fleming, Vicki; M. Lister, Michelle; C. Howson‐Wells, Hannah; Berry, Louise; Boswell, Tim; Joseph, Amelia; Willingham, Iona; Bird, Paul; Helmer, Thomas; Fallon, Karlie; W. Holmes, Christopher; W. Tang, Julian; Raviprakash, Veena; Campbell, Sharon; Sheriff, Nicola; Loose, Matthew; Holmes, Nadine; Moore, Christopher; Carlile, Matthew; Wright, Victoria; Sang, Fei; Debebe, Johnny; Coll, Francesc; W. Signell, Adrian; Betancor, Gilberto; Wilson, Harry; Feltwell, Theresa; J. Houldcroft, Charlotte; Eldirdiri, Sahar; Kenyon, Anita; Davis, Thomas; G. Pybus, Oliver; du Plessis, Louis; E. Zarebski, Alex; Raghwani, Jayna; U. G. Kraemer, Moritz; François, Sarah; W. Attwood, Stephen; I. Vasylyeva, Tetyana; Estée Török, M.; L. Hamilton, William; Goodfellow, Ian; Hall, Grant; S. Jahun, Aminu; Chaudhry, Yasmin; Hosmillo, Myra; L. Pinckert, Malte; Georgana, Iliana; Yakovleva, Anna; W. Meredith, Luke; Moses, Samuel; Lowe, Hannah; Ryan, Felicity; L. Fisher, Chloe; Raza Awan, Ali; Boyes, John; Breuer, Judith; Harris, Kathryn; R. Brown, Julianne; Shah, Divya; Atkinson, Laura; C. D. Lee, Jack; Alcolea-Medina, Adela; Moore, Nathan; Cortes, Nicholas; Williams, Rebecca; Chapman, Michael; J. Levett, Lisa; Heaney, Judith; Smith, Darren; Bashton, Matthew; R. Young, Gregory; N. Allan, John; P. Loh, Joshua; Randell, Paul; D. Cox, Alison; Madona, Pinglawathee; Holmes, Alison; Bolt, Frances; Price, James; Mookerjee, Siddharth; Rowan, Aileen; P. Taylor, Graham; Ragonnet‐Cronin, Manon; F. Nascimento, Fabricia; Jorgensen, David; Siveroni, Igor; Johnson, Rob; Boyd, Olivia; Geidelberg, Lily; Volz, Erik; Brunker, Kirstyn; Smollett, Katherine; J. Loman, Nicholas; Quick, Joshua; McMurray, Claire; Stockton, Joanne; Nicholls, Sam; Rowe, Will; Poplawski, Radoslaw; T. Martínez-Nuñez, Rocío; Mason, Jenifer; I. Robinson, Trevor; O’Toole, Elaine; Watts, Joanne; Breen, Cassie; Cowell, Angela; Ludden, Catherine; Sluga, Graciela; W. Machin, Nicholas; S.Y. Ahmad, Shazaad; P. George, Ryan; Halstead, Fenella; Sivaprakasam, Venkat; C. Thomson, Emma; G. Shepherd, James; Asamaphan, Patawee; Niebel, Marc; Li, Kathy; Shah, Rajiv; Jesudason, Natasha; A. Parr, Yasmin; Tong, L.; Broos, Alice; Mair, Daniel; Nichols, Jenna; Carmichael, Stephen; Nomikou, Kyriaki; Aranday-Cortés, Elihú; Johnson, Natasha; Starinskij, Igor; da Silva Filipe, Ana; L. Robertson, David; Orton, Richard; Hughes, Joseph; B. Sreenu, Vattipally; B. Singer, Joshua; Hale, Antony; Macfarlane-Smith, Louissa; L. Harper, Katherine; Taha, Yusri; Payne, Brendan; Burton-Fanning, Shirelle; Waugh, Sheila; Collins, Jennifer; Eltringham, Gary; Templeton, Kate; McHugh, M.; Dewar, Rebecca; Wastenge, Elizabeth; Dervisevic, Samir; Stanley, Rachael; Prakash, Reenesh; Stuart, Claire; Elumogo, Ngozi; Sethi, Dheeraj; Meader, Emma; Coupland, Lindsay; Potter, Will; Graham, Clive; Barton, Edward; Padgett, Debra; Scott, Garren; Swindells, Emma; Greenaway, Jane; Nelson, Andrew; C. Yew, Wen; C. Resende Silva, Paola; Andersson, Monique; H. Shaw, R.; Peto, Tim; Justice, Anita; W. Eyre, David; Crooke, Derrick; Hoosdally, Sarah; J. Sloan, Tim; Duckworth, Nichola; Walsh, Sarah; Chauhan, Anoop; Glaysher, Sharon; Bicknell, Kelly; Wyllie, Sarah; Butcher, Ethan; Elliott, Scott; Lloyd, Allyson; Impey, Robert; Levene, Nick; Monaghan, Lynn; Bradley, Declan; Allara, Elias; Pearson, Clare; Muir, Peter; B. Vipond, Ian; Hopes, Richard; M. Pymont, Hannah; Hutchings, Stephanie; D. Curran, Martin; Parmar, Surendra; Lackenby, Angie; Mbisa, Tamyo; G. Platt, Steven; Miah, Shahjahan; Bibby, David; de Guerrero Manso, Carmen; Hubb, Jonathan; Chand, Meera; Dabrera, Gavin; Ramsay, Mary; Bradshaw, Daniel; Thornton, Alicia; Myers, Richard; Schaefer, Ulf; Groves, Natalie; Gallagher, Eileen; Lee, David; A. Williams, David; Ellaby, Nicholas; Harrison, Ian; Hartman, Hassan; Manesis, Nikos; Patel, Vineet; Bishop, Chloe; Chalker, Vicki; Osman, Husam; Bosworth, Andrew; Robinson, Esther; T. G. Holden, Matthew; Shaaban, Sharif; Birchley, Alec; Adams, Alexander; Davies, Alisha; Gaskin, Amy; Plimmer, Amy; Gatica-Wilcox, Bree; McKerr, Caoimhe; Moore, Catherine; Williams, Chris; Heyburn, David; De Lacy, Elen; Hilvers, Ember; Downing, Fatima; Shankar, Giri; Jones, Hannah; Asad, Hibo; D. Coombes, Jason; Watkins, Joanne; M. Evans, Johnathan; Fina, Laia; Gifford, Laura; Gilbert, Lauren; Graham, Lee; Perry, Malorie; Morgan, Mari; Bull, Matthew; Cronin, Michelle; Pacchiarini, Nicole; Craine, Noel; Jones, Rachel; Howe, Robin; Corden, Sally; Rey, Sara; Kumziene-Summerhayes, Sara; Taylor, Sarah; Cottrell, Simon; Jones, Sophie; Edwards, Sue; O’Grady, Justin; J. Page, Andrew; Wain, John; Webber, Mark; E. Mather, Alison; Baker, David; Rudder, Steven; Yasir, Muhammad; M. Thomson, Nicholas; Aydin, Alp; P. Tedim, Ana; L. Kay, Gemma; J. Trotter, Alexander; Gilroy, Rachel; Alikhan, Nabil-Fareed; de Oliveira Martins, Leonardo; Le-Viet, Thanh; Meadows, Lizzie; Kolyva, Anastasia; Díaz, María; Bell, Andrew; Victoria Gutiérrez, Ana; G. Charles, Ian; M. Adriaenssens, Evelien; A. Kingsley, Robert; Casey, Anna; Simpson, David; Molnár, Zoltán; Thompson, Thomas; Acheson, Erwan; Masoli, Jane; Knight, Bridget; T. 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Green, Luke; Wang, Dennis; M. Freeman, Timothy; D. Parker, Matthew; J. Keeley, Alexander; J. Parsons, Paul; Tucker, Rachel; Brown, Rebecca; Wyles, Matthew; Constantinidou, Chrystala; Unnikrishnan, Meera; Ott, Sascha; K. J. Cheng, Jeffrey; E. Bridgewater, Hannah; R. Frost, Lucy; Taylor-Joyce, Grace; Stark, Richard; Baxter, Laura; Tauqeer Alam, Mohammad; E. Brown, Paul; Patrick McClure, C.; Chappell, Joseph; Tsoleridis, Theocharis; K. Ball, Jonathan; Grammatopoulos, Dimitris; Buck, David; A. Todd, John; Green, Angie; Trebes, Amy; MacIntyre-Cockett, George; de Cesare, Mariateresa; Langford, Cordelia; Alderton, Alex; Amato, Roberto; Gonçalves, Sónia; K. Jackson, David; Johnston, Ian; Sillitoe, John; Palmer, Steve; Lawniczak, Mara; Berriman, Matthew; Danesh, John; Livett, Rich; Shirley, Lesley; W. Farr, Ben; Quail, Mike; Thurston, Scott; Park, Naomi; Betteridge, Emma; Weldon, Danni; Goodwin, Scott; Nelson, Rachel; Beaver, Charlotte; Letchford, Laura; A. Jackson, David; Foulser, Luke; McMinn, Liz; Prestwood, Liam; Kay, Sally; Kane, Leanne; J. Dorman, Matthew; Martincorena, Inigo; Puethe, Christoph; Keatley, Jon-Paul; Tonkin‐Hill, Gerry; Smith, Christen; Jamrozy, Dorota; A. Beale, Mathew; Patel, Minal; V. Ariani, Cristina; Spencer-Chapman, Michael; Drury, Eleanor; W. Lo, Stephanie; Rajatileka, Shavanthi; Scott, Carol; James, Keith; K. Buddenborg, Sarah; Berger, Duncan; Patel, Gaurang; V. Garcia-Casado, Maria; Dibling, Thomas; McGuigan, Samantha; Rogers, Hazel; D. Hunter, Adam; Souster, Emily; Neaverson, Alexandra; Goodfellow, Ian; J. Loman, Nicholas; G. Pybus, Oliver; L. Robertson, David; C. Thomson, Emma; Rambaut, Andrew; R. Connor, Thomas

doi:10.1016/j.cell.2020.11.020

Public

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Published in Cell • Nov 18, 2020

Authors:

Erik Volz

Verity Hill

John T. McCrone

Abstract

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genom...

Subject

Biology

Transmissibility (structural dynamics)

Spike (software development)

Research Assistant

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