Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways

Xiao, Long; Zhong, Mengdan; Huang, Yu; Zhu, Jie; Tang, Wenkai; Li, Danyong; Shi, Jiandong; Lu, Aiqing; Yang, Huilin; Geng, Dechun; Li, Hong; Wang, Zhirong

doi:10.18632/aging.103976

Public

Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways

Published in Aging • Nov 7, 2020

Authors:

Long Xiao

Mengdan Zhong

Yu Huang

Abstract

osteoclast differentiation, hydroxyapatite resorption activity, and expression of osteoclastogenesis-related genes, such as NFATc1, MMP9, CTSK, Acp5 and c-Fos, in RANKL-induced bone marrow macrophages (BMMs) and RAW264.7 cells. It also reduced intracellular ROS levels by suppressing expression of TR...

Subject

Puerarin

NF-κB

MAPK/ERK pathway

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