Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected

Suárez‐Calvet, Marc; K. Karikari, Thomas; J Ashton, Nicholas; Lantero‐Rodriguez, Juan; Milà‐Alomà, Marta; Domingo Gispert, Juan; Salvadó, Gemma; Minguillón, Carolina; Fauria, Karine; Shekari, Mahnaz; Grau‐Rivera, Oriol; M. Arenaza‐Urquijo, Eider; Sala‐Vila, Aleix; Sánchez‐Benavides, Gonzalo; María Gónzalez‐de‐Echávarri, José; Kollmorgen, Gwendlyn; Stoops, Erik; Vanmechelen, Eugeen; Zetterberg, Henrik; Blennow, Kaj; Luís Molinuevo, José; the ALFA Study, for; Beteta, Annabella; Cacciaglia, Raffaele; Cañas, Alba; Deulofeu, Carme; Cumplido, Irene; Dominguez, Ruth; Emilio, Maria; Falcón, Carles; Fuentes, Sherezade; L. Hernandez, Laura; Huesa, Gema; Huguet, Jordi; Marne, Paula; Menchón, Tania; Operto, Grégory; Polo, Albina; Pradas, Sandra; Soteras, Anna; Vilanova, Marc; Vilor‐Tejedor, Natàlia

doi:10.15252/emmm.202012921

Public

Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected

Published in EMBO Molecular Medicine • Nov 10, 2020

Authors:

Marc Suárez‐Calvet

Thomas K. Karikari

Nicholas J Ashton

Abstract

In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was to characterize the pattern of changes in phosphorylated tau (p-tau) in the prec...

Subject

Phosphorylation

Neuroscience

Pathology

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