Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25

Kuang, Yaoyun; Zheng, Xuan; Zhang, Lin; Ai, Xiaoyu; Venkataramani, Vivek; Kılıç, Ertuğrul; M. Hermann, Dirk; Majid, Arshad; Bähr, Mathias; R. Doeppner, Thorsten

doi:10.1002/jev2.12024

Public

Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25

Published in Journal of Extracellular Vesicles • Nov 1, 2020

Authors:

Yaoyun Kuang

Xuan Zheng

Lin Zhang

Abstract

Abstract Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has not yet been identified. To investigate such cargo and its underlying mechanism, primary neurons were exposed to...

Subject

Autophagy

Mesenchymal stem cell

Extracellular vesicles

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