EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity

K. Gandhi, Maher; Hoang, Thanh; Cheng Law, Soi; Brosda, Sandra; O’Rourke, Kacey; W.D. Tobin, Joshua; Vari, Frank; Murigneux, Valentine; Lynn Fink, J.; Gunawardana, Jay; Gould, Clare; Oey, Harald; Bednarska, Karolina; Delécluse, Susanne; Ulrich Trappe, Ralf; Merida de Long, Lilia; B. Sabdia, Muhammed; Bhagat, Govind; Hapgood, Greg; Blyth, Emily; Clancy, Luke; Wight, Joel; A. Hawkes, Eliza; M. Rimsza, Lisa; Maguire, A.; Bojarczuk, Kamil; Chapuy, Bjoern; Keane, Colm

doi:10.1182/blood.2020008520

Public

EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity

Published in Blood • Nov 17, 2020

Authors:

Maher K. Gandhi

Thanh Hoang

Soi Cheng Law

Abstract

Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression (eg, posttransplant lymphoproliferative disorders or HIV [AIDS-related PCNSL]). These cases are poorly...

Subject

Primary central nervous system lymphoma

Immunosuppression

Lymphoproliferative disorders

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