SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

J. Hou, Yixuan; Chiba, Shiho; Halfmann, Peter; Ehre, Camille; Kuroda, Makoto; H. Dinnon, Kenneth; R. Leist, Sarah; Schäfer, Alexandra; Nakajima, Noriko; Takahashi, Kenta; E. Lee, Rhianna; M. Mascenik, Teresa; Graham, Rachel; E. Edwards, Caitlin; V. Tse, Longping; Okuda, Kenichi; J. Markmann, Alena; Bartelt, Luther; de Silva, Aravinda; M. Margolis, David; C. Boucher, Richard; H. Randell, Scott; Suzuki, Tadaki; E. Gralinski, Lisa; Kawaoka, Yoshihiro; S. Baric, Ralph

doi:10.1126/science.abe8499

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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Shared by NobleBlocks on Dec 18, 2020 • 12:00 AM UTC

Authors:

Yixuan J. Hou

Shiho Chiba

Peter Halfmann

Abstract

Changing with the times Pandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged from China has now been largely replaced by str...

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