Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

Zhao, Senlin; Mi, Yushuai; Guan, Bingjie; Zheng-Lin, Binbin; Wei, Ping; Gu, Yanzi; Zhang, Zhengxiang; Cai, Sanjun; Xu, Ye; Li, Xinxiang; He, Xuefeng; Zhong, Xinyang; Li, Guichao; Chen, Zhiyu; Li, Dawei

doi:10.1186/s13045-020-00991-2

Public

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

Published in Journal of Hematology & Oncology • Nov 19, 2020

Authors:

Senlin Zhao

Yushuai Mi

Bingjie Guan

Abstract

BACKGROUND: Mounting evidence has demonstrated the vital importance of tumor-associated macrophages (TAMs) and exosomes in the formation of the premetastatic niche. However, the molecular mechanisms by which tumor-derived exosomal miRNAs interact with TAMs underlying premetastatic niche formation an...

Subject

Medicine

Hematology

Colorectal cancer

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