PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy

Simon, Sylvain; Voillet, Valentin; Vignard, Virginie; Wu, Zhong; Dabrowski, Camille; Jouand, Nicolas; Beauvais, Tiffany; Khammari, Amir; Braudeau, Cécile; Josien, Régis; Adotévi, Olivier; Laheurte, Caroline; Aubin, F.; Nardin, C.; Rulli, Samuel; Gottardo, Raphaël; Ramchurren, Nirasha; A. Cheever, Martin; P. Fling, Steven; D. Church, Candice; Nghiem, Paul; Dréno, Brigitte; R. Riddell, Stanley; Labarrière, Nathalie

doi:10.1136/jitc-2020-001631

Public

PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy

Published in Journal for ImmunoTherapy of Cancer • Nov 1, 2020

Authors:

Sylvain Simon

Valentin Voillet

Virginie Vignard

Abstract

Background Clinical benefit from programmed cell death 1 receptor (PD-1) inhibitors relies on reinvigoration of endogenous antitumor immunity. Nonetheless, robust immunological markers, based on circulating immune cell subsets associated with therapeutic efficacy are yet to be validated. Methods We ...

Subject

TIGIT

CD8

Cytotoxic T cell

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