Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation

Zeng, Zhi; Xia, Luoxing; Fan, Shunyang; Zheng, Junmeng; Qin, Jinhong; Fan, Xuejiao; Liu, Yunfeng; Tao, Jun; Liu, Yingying; Li, Kang; Ling, Zhenwei; Bu, Yun; A. Martin, Kathleen; Hwa, John; Liu, Renjing; Ho Tang, Wai

doi:10.1161/circulationaha.120.049715

Public

Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation

Published in Circulation • Nov 19, 2020

Authors:

Zhi Zeng

Luoxing Xia

Shunyang Fan

Abstract

BACKGROUND: Aberrant expression of circular RNA contributes to human diseases. Circular RNAs regulate gene expression by sequestering specific microRNAs. In this study, we investigated whether circMAP3K5 (circular mitogen-activated protein kinase 5) could act as a competing endogenous microRNA-22-3p...

Subject

Neointima

Intimal hyperplasia

Medicine

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