Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

J. Nicholls, Stephen; Michael Lincoff, A.; Garcia, Michelle; Bash, Dianna; M. Ballantyne, Christie; J. Barter, Philip; H. Davidson, Michael; J.P. Kastelein, John; Köenig, Wolfgang; K. McGuire, Darren; Mozaffarian, Dariush; M. Ridker, Paul; K. Ray, Kausik; G. Katona, Brian; Himmelmänn, Anders; E. Loss, Larrye; Rensfeldt, Martin; Lundström, Torbjörn; Agrawal, Rahul; Menon, Venu; Wolski, Kathy; E. Nissen, Steven

doi:10.1001/jama.2020.22258

Public

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

Published in JAMA • Nov 15, 2020

Authors:

Stephen J. Nicholls

A. Michael Lincoff

Michelle Garcia

Abstract

Importance: It remains uncertain whether the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce cardiovascular risk. Objective: To determine the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and DHA (omega-3 CA) with documented favorabl...

Subject

Medicine

Adverse effect

Corn oil

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