STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Boudewijns, Robbert; Jan Thibaut, Hendrik; J. F. Kaptein, Suzanne; Li, Rong; Vergote, Valentijn; Seldeslachts, Laura; Van Weyenbergh, Johan; De Keyzer, Carolien; Bervoets, Lindsey; Sharma, Sapna; Liesenborghs, Laurens; Ma, Ji; Jansen, Sander; Van Looveren, Dominique; Vercruysse, Thomas; Wang, Xinyu; Jochmans, Dirk; Martens, Erik; Roose, Kenny; De Vlieger, Dorien; Schepens, Bert; Van Buyten, Tina; Jacobs, Sofie; Liu, Yanan; Martí‐Carreras, Joan; Vanmechelen, Bert; Wawina-Bokalanga, Tony; Delang, Leen; Rocha‐Pereira, Joana; Coelmont, Lotte; Chiu, Winston; Leyssen, Pieter; Heylen, Elisabeth; Schols, Dominique; Wang, Lanjiao; Close, Lila; Matthijnssens, Jelle; Van Ranst, Marc; Compernolle, Veerle; Schramm, Georg; Van Laere, Koen; Saelens, Xavier; Callewaert, Nico; Opdenakker, Ghislain; Maes, Piet; Weynand, Birgit; Cawthorne, Christopher; Vande Velde, Greetje; Wang, Zhongde; Neyts, Johan; Dallmeier, Kai

doi:10.1038/s41467-020-19684-y

Public

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Published in Nature Communications • Nov 17, 2020

Authors:

Robbert Boudewijns

Hendrik Jan Thibaut

Suzanne J. F. Kaptein

Abstract

Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS...

Subject

Pathogenesis

Innate immune system

Interferon

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