BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

J.C.F.M. Moorlag, Simone; Alina Rodriguez-Rosales, Yessica; Gillard, Joshua; Fanucchi, Stephanie; Theunissen, Kate; Novakovic, Boris; M. de Bont, Cynthia; Negishi, Yutaka; T. Fok, Ezio; Kalafati, Lydia; Verginis, Panayotis; P. Mourits, Vera; A. C. M. Koeken, Valerie; Charlotte J. de Bree, L.; J.M. Pruijn, Ger; Fenwick, Craig; van Crevel, Reinout; A. B. Joosten, Leo; Joosten, Irma; J. P. M. Koenen, Hans; M. Mhlanga, Musa; A. Diavatopoulos, Dimitri; Chavakis, Triantafyllos; G. Netea, Mihai

doi:10.1016/j.celrep.2020.108387

Public

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Published in Cell Reports • Nov 1, 2020

Authors:

Simone J.C.F.M. Moorlag

Yessica Alina Rodriguez-Rosales

Joshua Gillard

Abstract

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of train...

Subject

Innate immune system

Immunology

Reprogramming

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