Autophagy-mediated metabolic effects of aspirin.

Francesca, Castoldi,; Juliette, Humeau,; Isabelle, Martins,; Sylvie, Lachkar,; Damarys, Loew,; Florent, Dingli,; Sylvère, Durand,; David, Enot,; Noëlie, Bossut,; Alexis, Chery,; Fanny, Aprahamian,; Yohann, Demont,; Paule, Opolon,; Nicolas, Signolle,; Allan, Sauvat,; Michaela, Semeraro,; Lucillia, Bezu,; Elisa Elena, Baracco,; Erika, Vacchelli,; Jonathan G, Pol,; Sarah, Lévesque,; Norma, Bloy,; Valentina, Sica,; Maria Chiara, Maiuri,; Guido, Kroemer,; Federico, Pietrocola,

doi:10.1038/s41420-020-00365-0

Public

Autophagy-mediated metabolic effects of aspirin.

Published in Cell death discovery • Nov 24, 2020

Authors:

Castoldi, Francesca

Humeau, Juliette

Martins, Isabelle

Abstract

Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300. Here, we directly compared the metabolic effects of aspirin medication with ...

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