Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Meinhardt, Jenny; Radke, Josefine; Dittmayer, Carsten; Franz, Jonas; Thomas, Carolina; Mothes, Ronja; Laue, Michael; Schneider, Julia; Brünink, Sebastian; Greuel, Selina; Lehmann, Malte; Hassan, Olga; Aschman, Tom; Schumann, Elisa; Lorenz Chua, Robert; Conrad, Christian; Eils, Roland; Stenzel, Werner; Windgassen, Marc; Rößler, Larissa; Goebel, Hans‐Hilmar; R. Gelderblom, Hans; Martin, Hubert; Nitsche, Andreas; Schulz‐Schaeffer, Walter; Hakroush, Samy; Sebastian Winkler, Martin; Tampe, Björn; Scheibe, Franziska; Körtvelyessy, Péter; Reinhold, Dirk; Siegmund, Britta; A. Kühl, Anja; Elezkurtaj, Sefer; Horst, David; Oesterhelweg, Lars; Tsokos, Michael; Ingold‐Heppner, Barbara; Stadelmann, Christine; Drosten, Christian; M. Corman, Victor; Radbruch, Helena; L. Heppner, Frank

doi:10.1038/s41593-020-00758-5

Public

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Published in Nature Neuroscience • Nov 30, 2020

Authors:

Jenny Meinhardt

Josefine Radke

Carsten Dittmayer

Abstract

The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individua...

Subject

Central nervous system

Olfactory system

Medulla oblongata

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