Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs.

WH, Chou; A, Galaz; MO, Jara; A, Gamboa; JO, Morales

doi:10.3390/pharmaceutics12121168

Public

Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs.

Shared by NobleBlocks on Nov 30, 2020 • 12:00 AM UTC

Authors:

Chou WH

Galaz A

Jara MO

Abstract

The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding ...

Subject

In vitro release

Mechanical properties

Human insulin

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