Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors

Cheng, Binbin; Xiao, Yao; Xue, Mingming; Cao, Hao; Chen, Jianjun

doi:10.1021/acs.jmedchem.0c01362

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Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors

Published in Journal of Medicinal Chemistry • Dec 4, 2020

Authors:

Binbin Cheng

Yao Xiao

Mingming Xue

Abstract

Therapeutic interference of the programmed cell death protein 1(PD-1)/immunosuppressive programmed cell death ligand 1 (PD-L1) signaling pathway by monoclonal antibodies has achieved spectacular success for treating various tumors. However, the development of small molecule inhibitors of PD-1/PD-L1 ...

Subject

Chemistry

Small molecule

Covalent bond

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