Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA Damage

Fayyad, Nour; Kobaisi, Farah; Béal, David; Mahfouf, Walid; Ged, Cécile; Morice‐Picard, Fanny; Fayyad‐Kazan, Mohammad; Fayyad‐Kazan, Hussein; Badran, Bassam; Rezvani, Hamid; Rachidi, Walid

doi:10.3389/fgene.2020.561687

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Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA Damage

Published in Frontiers in Genetics • Nov 27, 2020

Authors:

Nour Fayyad

Farah Kobaisi

David Béal

Abstract

Xeroderma Pigmentosum C (XPC) is a multi-functional protein that is involved not only in the repair of bulky lesions, post-irradiation, via nucleotide excision repair (NER) per se but also in oxidative DNA damage mending. Since base excision repair (BER) is the primary regulator of oxidative DNA dam...

Subject

Xeroderma pigmentosum

Base excision repair

Nucleotide excision repair

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