Five‐Membered Nitrogen Heterocycles Synthesis through 1,3‐Dipolar Cycloaddition of Non‐Stabilized Azomethine Ylides with 2‐Pyridone Heteroaromatic Systems as Dipolarophiles

Ben Salah, Sami; Sanselme, Morgane; Champavier, Yves; Othman, Mohamed; Daı̈ch, Adam; Chataigner, Isabelle; Martin Lawson, Ata

doi:10.1002/ejoc.202001404

Public

Five‐Membered Nitrogen Heterocycles Synthesis through 1,3‐Dipolar Cycloaddition of Non‐Stabilized Azomethine Ylides with 2‐Pyridone Heteroaromatic Systems as Dipolarophiles

Published in European Journal of Organic Chemistry • Dec 11, 2020

Authors:

Sami Ben Salah

Morgane Sanselme

Yves Champavier

Abstract

Abstract We report an efficient 1,3‐dipolar cycloaddition involving non‐stabilized electron‐rich azomethine ylides and diversely substituted 2‐pyridones bearing two potential C=C dipolarophilic sites. The 1,3‐dipoles were prepared in situ under TFA catalysis and cycloadditions were studied according...

Subject

Cycloaddition

Chemistry

Regioselectivity

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