Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Psarras, Antonios; Alase, Adewonuola; Antanaviciute, Agne; Carr, Ian; Yuzaiful Md Yusof, Md; Wittmann, Miriam; Emery, Paul; C. Tsokos, George; M Vital, Edward

doi:10.1038/s41467-020-19918-z

Public

Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Published in Nature Communications • Dec 1, 2020

Authors:

Antonios Psarras

Adewonuola Alase

Agne Antanaviciute

Abstract

Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmunity. Type I interferons have a crucial role in the progression to established autoimmune diseases. The cellular source and regulation in disease initiation of these cytokines is not clear, but pl...

Subject

Autoimmunity

Plasmacytoid dendritic cell

Immunology

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