Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

Castel, Gaël; Meistermann, Dimitri; Bretin, Betty; Firmin, Julie; Blin, Justine; Loubersac, Sophie; Bruneau, Alexandre; Chevolleau, Simon; Kilens, Stéphanie; Chariau, Caroline; Gaignerie, Anne; Francheteau, Quentin; Kagawa, Harunobu; Charpentier, Éric; Flippe, Léa; François-Campion, Valentin; Haider, Sandra; Dietrich, Bianca; Knöfler, Martin; Arima, Takahiro; Bourdon, Jérémie; Rivron, Nicolas; Masson, Damien; Fournier, Thierry; Okae, Hiroaki; Fréour, Thomas; David, Laurent

doi:10.1016/j.celrep.2020.108419

Public

Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

Published in Cell Reports • Nov 1, 2020

Authors:

Gaël Castel

Dimitri Meistermann

Betty Bretin

Abstract

Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester cytotrophoblasts offer an unprecedented opportunity to study the placenta. However, access to human embryos and first-trimester placentas is limited, thus preventing the establishment of hTSCs from diverse genetic back...

Subject

SOX2

Biology

Induced pluripotent stem cell

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