Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Zang, Ruochen; Brett Case, James; Yutuc, Eylan; Ma, Xiucui; Shen, Sheng; Florencia Gómez Castro, María; Liu, Zhuoming; Zeng, Qiru; Zhao, Haiyan; Son, Juhee; W. Rothlauf, Paul; J.B. Kreutzberger, Alex; Hou, Gaopeng; Zhang, Hu; Bose, Sayantan; Wang, Xin; D. Vahey, Michael; Mani, Kartik; J. Griffiths, William; Kirchhausen, Tomas; H. Fremont, Daved; Guo, Haitao; Diwan, Abhinav; Wang, Yuqin; Diamond, Michael; P. J. Whelan, Sean; Ding, Siyuan

doi:10.1073/pnas.2012197117

Public

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Published in Proceedings of the National Academy of Sciences • Nov 25, 2020

Authors:

Ruochen Zang

James Brett Case

Eylan Yutuc

Abstract

) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-stimulated gene screen against vesicular stomatitis virus (VSV)-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH25H and its enzymatic product 25-...

Subject

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus

Virology

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