N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Xu, Junjie; Wan, Zhe; Tang, Minyue; Lin, Zhongjie; Shi, Jiang; Ji, Lin; Gorshkov, Kirill; Mao, Qijiang; Xia, Shunjie; Cen, Dong; Zheng, Junhao; Liang, Xiao; Cai, Xiujun

doi:10.1186/s12943-020-01281-8

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N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Published in Molecular Cancer • Nov 23, 2020

Authors:

Junjie Xu

Zhe Wan

Minyue Tang

Abstract

Abstract Background and aims Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understanding these mechanisms will enhance the likelihood of effective ...

Subject

Sorafenib

Cancer research

Small interfering RNA

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