Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Govaere, Olivier; Cockell, Simon; Tiniakos, Dina; Queen, Rachel; Younes, Ramy; Vacca, Michèle; Alexander, Leigh; Ravaioli, Federico; M. Palmer, Jeremy; Petta, Salvatore; Boursier, Jérôme; Rosso, Chiara; Johnson, Katherine; Wonders, Kristy; P. Day, Christopher; Ekstedt, Mattias; Orešič, Matej; Darlay, Rebecca; J. Cordell, Heather; Marra, Fabio; Vidal‐Puig, Antonio; Bédossa, Pierre; M. Schattenberg, Jörn; Clément, Karine; Allison, Michael; Bugianesi, Elisabetta; Ratziu, Vlad; K. Daly, Ann; M. Anstee, Quentin

doi:10.1126/scitranslmed.aba4448

Public

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Published in Science Translational Medicine • Dec 2, 2020

Authors:

Olivier Govaere

Simon Cockell

Dina Tiniakos

Abstract

, whereas GDF15 supplementation tempered the inflammatory response in macrophages upon lipid loading and lipopolysaccharide stimulation. This study provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potent...

Subject

Nonalcoholic steatohepatitis

Gene signature

Nonalcoholic fatty liver disease

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!